{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T05:02:31Z","timestamp":1777352551327,"version":"3.51.4"},"reference-count":74,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"586","funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["PTDC\/SAU-NEU\/104297\/2008 and POCI-01-0145-FEDER-028656"],"award-info":[{"award-number":["PTDC\/SAU-NEU\/104297\/2008 and POCI-01-0145-FEDER-028656"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["PEst-C\/SAU\/LA0001\/2013-2014, UID\/NEU\/04539\/2013 and UID\/BIM\/4501\/2013"],"award-info":[{"award-number":["PEst-C\/SAU\/LA0001\/2013-2014, UID\/NEU\/04539\/2013 and UID\/BIM\/4501\/2013"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Signal."],"published-print":{"date-parts":[[2019,6,18]]},"abstract":"<jats:p>The RNA binding protein hnRNP K mediates BDNF-induced proteome remodeling at the neuronal synapse.<\/jats:p>","DOI":"10.1126\/scisignal.aav3577","type":"journal-article","created":{"date-parts":[[2019,6,18]],"date-time":"2019-06-18T23:15:42Z","timestamp":1560899742000},"source":"Crossref","is-referenced-by-count":39,"title":["BDNF increases synaptic NMDA receptor abundance by enhancing the local translation of Pyk2 in cultured hippocampal neurons"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9198-9015","authenticated-orcid":true,"given":"Pedro","family":"Afonso","sequence":"first","affiliation":[{"name":"CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal."},{"name":"Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal."}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1113-2135","authenticated-orcid":true,"given":"Pasqualino","family":"De Luca","sequence":"additional","affiliation":[{"name":"CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal."},{"name":"Institute for Interdisciplinary Research, University of Coimbra (IIIUC), 3030-790 Coimbra, Portugal."}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2104-9770","authenticated-orcid":true,"given":"Rafael S.","family":"Carvalho","sequence":"additional","affiliation":[{"name":"CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal."}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5292-4369","authenticated-orcid":true,"given":"Lu\u00edsa","family":"Cortes","sequence":"additional","affiliation":[{"name":"CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal."},{"name":"Institute for Interdisciplinary Research, University of Coimbra (IIIUC), 3030-790 Coimbra, Portugal."}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9024-1021","authenticated-orcid":true,"given":"Paulo","family":"Pinheiro","sequence":"additional","affiliation":[{"name":"CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal."},{"name":"Institute for Interdisciplinary Research, University of Coimbra (IIIUC), 3030-790 Coimbra, Portugal."}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7836-8161","authenticated-orcid":true,"given":"Barbara","family":"Oliveiros","sequence":"additional","affiliation":[{"name":"Laboratory of Biostatistics and Medical Informatics, Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal."},{"name":"Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal."}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5830-2595","authenticated-orcid":true,"given":"Ramiro D.","family":"Almeida","sequence":"additional","affiliation":[{"name":"CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal."},{"name":"Health Sciences Program, Department of Medical Sciences, Institute of Biomedicine - iBiMED, University of Aveiro, 3810-193 Aveiro, Portugal."}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8627-4883","authenticated-orcid":true,"given":"Miranda","family":"Mele","sequence":"additional","affiliation":[{"name":"CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal."},{"name":"Institute for Interdisciplinary Research, University of Coimbra (IIIUC), 3030-790 Coimbra, Portugal."}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1474-0208","authenticated-orcid":true,"given":"Carlos B.","family":"Duarte","sequence":"additional","affiliation":[{"name":"CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal."},{"name":"Department of Life Sciences, University of Coimbra, 3000-456 Coimbra, Portugal."}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2005.06.003"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3379"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2738"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2013.04.005"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/bs.vh.2016.10.004"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.273.5280.1402"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1739-04.2004"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1427-04.2004"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2883-07.2007"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.10.016"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.02-03-00284.1982"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.07.022"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M500255-MCP200"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.11.002"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0104-08.2008"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0268-17.2017"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.042693699"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-009-1959-2"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1124\/pr.109.002451"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199212000-00027"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903470112"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(94)90210-0"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3504"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2153"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2008.07.046"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1113\/JP275226"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/syn.20090"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.90880.2008"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2006.08.129"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.13295"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2007.02.019"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1124\/mol.58.3.614"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2011.05.009"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3349-07.2007"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00220-3"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/76615"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(98)01358-7"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1368"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1517\/14728220903473194"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3319"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-014-8796-4"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.09.099"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4992-08.2010"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/375325a0"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/43432"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2011.482"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/90498"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M008085200"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2011.453"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbiomolbio.2015.06.001"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/383547a0"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-015-9335-7"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1001923"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0289-13.2013"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2003.02712.x"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0040133"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00295-1"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3246"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0108175"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15592"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M700607200"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4521-14.2015"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1021\/pr900366x"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2006.356"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2432-08.2008"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1219605110"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn1270"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4921"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.04.017"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3302305"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-03-563981"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1006\/mthe.2001.0282"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201509039"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(06)06046-0"}],"container-title":["Science Signaling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1126\/scisignal.aav3577","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scisignal.aav3577","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T12:38:32Z","timestamp":1705408712000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scisignal.aav3577"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,18]]},"references-count":74,"journal-issue":{"issue":"586","published-print":{"date-parts":[[2019,6,18]]}},"alternative-id":["10.1126\/scisignal.aav3577"],"URL":"https:\/\/doi.org\/10.1126\/scisignal.aav3577","relation":{},"ISSN":["1945-0877","1937-9145"],"issn-type":[{"value":"1945-0877","type":"print"},{"value":"1937-9145","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,18]]},"article-number":"eaav3577"}}