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Using a mouse model, we found that prior HCoV-OC43 S\u2013targeted immunity primes neutralizing antibody responses to otherwise subimmunogenic SARS-CoV-2 S exposure and promotes S2-targeting antibody responses. Moreover, vaccination with SARS-CoV-2 S2 elicited antibodies in mice that neutralized diverse animal and human alphacoronaviruses and betacoronaviruses in vitro and provided a degree of protection against SARS-CoV-2 challenge in vivo. Last, in mice with a history of SARS-CoV-2 Wuhan\u2013based S vaccination, further S2 vaccination induced broader neutralizing antibody response than booster Wuhan S vaccination, suggesting that it may prevent repertoire focusing caused by repeated homologous vaccination. These data establish the protective value of an S2-targeting vaccine and support the notion that S2 vaccination may better prepare the immune system to respond to the changing nature of the S1 subunit in SARS-CoV-2 variants of concern, as well as to future coronavirus zoonoses.<\/jats:p>","DOI":"10.1126\/scitranslmed.abn3715","type":"journal-article","created":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T13:56:47Z","timestamp":1658930207000},"source":"Crossref","is-referenced-by-count":109,"title":["RETRACTED: SARS-CoV-2 S2\u2013targeted vaccination elicits broadly neutralizing antibodies"],"prefix":"10.1126","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1635-6768","authenticated-orcid":true,"given":"Kevin W.","family":"Ng","sequence":"first","affiliation":[{"name":"Retroviral Immunology, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, 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