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Med."],"published-print":{"date-parts":[[2026,7,22]]},"abstract":"<jats:p>\n                    Two live-attenuated vaccines, LMA and LMP, were evaluated alone or in combination with a trivalent adenoviral vector\u2013based vaccine (Ad5-YFV) for their protective efficacy against pneumonic plague in wild-type (WT) and interferon-\u03b3 (IFN-\u03b3) knockout (KO) mice. LMA and LMP comprise triple deletion mutants of\n                    <jats:italic toggle=\"yes\">Yersinia pestis<\/jats:italic>\n                    CO92, which causes pneumonic plague, and Ad5-YFV incorporates three protective plague immunogens. Protection of 80 to 100% was observed in vaccinated mice when challenged with highly lethal intranasal doses of parental\n                    <jats:italic toggle=\"yes\">Y. pestis<\/jats:italic>\n                    CO92. All vaccinated mice generated robust humoral and cellular immune responses. Immunized WT mice generated overall greater antibody responses in both serum and bronchoalveolar lavage fluid with higher percentages of polyfunctional T cell populations. Vaccinated IFN-\u03b3 KO mice displayed better B cell activity in germinal centers with higher percentages of activated antigen-specific and memory T cells. Superior lung immunity and recall immune responses were observed in both WT and IFN-\u03b3 KO mice immunized using a prime-pull vaccine strategy, which also provided full protection against pneumonic plague to mice lacking IFN-\u03b1, IFN-\u03b2, and IFN-\u03b3 receptors. Depletion of IFN-\u03b3 or tumor necrosis factor\u2013\u03b1 from immunized WT mice before and during infection did not reduce protection against pulmonary\n                    <jats:italic toggle=\"yes\">Y. pestis<\/jats:italic>\n                    CO92 challenge. These data suggest that IFN-\u03b3 may not be required for protection against pneumonic plague by these vaccines. Combining live-attenuated and adenovirus-based vaccines resulted in augmentation of systemic and local immune responses, which could be beneficial in providing long-lasting immunity against pneumonic plague.\n                  <\/jats:p>","DOI":"10.1126\/scitranslmed.ads0514","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T17:58:19Z","timestamp":1784743099000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Live attenuated vaccines alone or in combination with an adenovirus-based vaccine protect mice lacking IFN-\u03b3 against pneumonic plague"],"prefix":"10.1126","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0374-3841","authenticated-orcid":true,"given":"Emily K.","family":"Hendrix","sequence":"first","affiliation":[{"name":"Department of Microbiology &amp; Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7638-9067","authenticated-orcid":true,"given":"Jian","family":"Sha","sequence":"additional","affiliation":[{"name":"Department of Microbiology &amp; Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA."},{"name":"Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX 77555, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2474-8120","authenticated-orcid":true,"given":"Paul B.","family":"Kilgore","sequence":"additional","affiliation":[{"name":"Department of Microbiology &amp; Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8091-0604","authenticated-orcid":true,"given":"Blake H.","family":"Neil","sequence":"additional","affiliation":[{"name":"Department of Microbiology &amp; Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8173-330X","authenticated-orcid":true,"given":"Atul K.","family":"Verma","sequence":"additional","affiliation":[{"name":"Department of Microbiology &amp; Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9420-5028","authenticated-orcid":true,"given":"Heidi","family":"Spratt","sequence":"additional","affiliation":[{"name":"School of Public and Population Health, University of Texas Medical Branch, Galveston, TX 77555, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5223-3012","authenticated-orcid":true,"given":"Ashok K.","family":"Chopra","sequence":"additional","affiliation":[{"name":"Department of Microbiology &amp; Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA."},{"name":"Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX 77555, USA."},{"name":"Sealy Institute for Vaccine Sciences, University of Texas Medical Branch, Galveston, TX 77555, USA."},{"name":"Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX 77555, USA."},{"name":"Center for Biodefense and Emerging Infectious Diseases, Galveston, TX 77555, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","unstructured":"World Health Organization Regional Office for Africa \u201cWeekly bulletin on outbreaks and other emergencies. 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