{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T01:04:06Z","timestamp":1793149446209,"version":"4.5.0"},"reference-count":43,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Seventy-two\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">A. fumigatus<\/jats:named-content>\n            clinical isolates from China were investigated for azole resistance based on mutations of\n            <jats:italic>cyp51A<\/jats:italic>\n            . We identified four azole-resistant strains, among which we found three strains highly resistant to itraconazole, two of which exhibit the TR34\/L98H\/S297T\/F495I mutation, while one carries only the TR34\/L98H mutation. To our knowledge, the latter has not been found previously in China. The fourth multiazole-resistant isolate (with only moderate itraconazole resistance) carries a new G432A mutation.\n          <\/jats:p>","DOI":"10.1128\/aac.00003-15","type":"journal-article","created":{"date-parts":[[2015,4,21]],"date-time":"2015-04-21T02:31:49Z","timestamp":1429583509000},"page":"4321-4325","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":55,"title":["Multiple\n            <i>cyp51A<\/i>\n            -Based Mechanisms Identified in Azole-Resistant Isolates of Aspergillus fumigatus from China"],"prefix":"10.1128","volume":"59","author":[{"given":"Musang","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Medical Mycology, Institute of Dermatology, Chinese Academy of Medical Science and Peking Union Medical College, Nanjing, Jiangsu, People's Republic of 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