{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:53:57Z","timestamp":1753880037630,"version":"3.41.2"},"reference-count":65,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2021,4,19]],"date-time":"2021-04-19T00:00:00Z","timestamp":1618790400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1128\/ASMCopyrightv2"},{"start":{"date-parts":[[2021,4,19]],"date-time":"2021-04-19T00:00:00Z","timestamp":1618790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2017\/22452-1"],"award-info":[{"award-number":["2017\/22452-1"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2021,4,19]]},"abstract":"<jats:p>Cerebral malaria (CM) is a severe immune vasculopathy which presents a high mortality rate (15 to 20%), despite the availability of artemisinin-based therapy. More effective immunomodulatory and\/or antiparasitic therapies are urgently needed.<\/jats:p>","DOI":"10.1128\/aac.00004-21","type":"journal-article","created":{"date-parts":[[2021,2,26]],"date-time":"2021-02-26T13:06:17Z","timestamp":1614344777000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":5,"title":["Perillyl Alcohol Reduces Parasite Sequestration and Cerebrovascular Dysfunction during Experimental Cerebral Malaria"],"prefix":"10.1128","volume":"65","author":[{"given":"Adriana A.","family":"Marin","sequence":"first","affiliation":[{"name":"Department of Parasitology, Institute of Biomedical Science, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oscar","family":"Murillo","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Institute of Biomedical Science, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo A.","family":"Sussmann","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Institute of Biomedical Science, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luana S.","family":"Ortolan","sequence":"additional","affiliation":[{"name":"Department of Immunology, Institute of Biomedical Science, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniella S.","family":"Battagello","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Institute of Biomedical Science, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thatyane","family":"de Castro Quirino","sequence":"additional","affiliation":[{"name":"Department of Clinical and Toxicological Analysis, Faculty of Pharmaceutical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jackson C.","family":"Bittencourt","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Institute of Biomedical Science, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabrina","family":"Epiphanio","sequence":"additional","affiliation":[{"name":"Department of Clinical and Toxicological Analysis, Faculty of Pharmaceutical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4782-2162","authenticated-orcid":true,"given":"Alejandro M.","family":"Katzin","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Institute of Biomedical Science, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo J. M.","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Laboratory of Malaria Research, Oswaldo Cruz Institute, Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.297.20.2232"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01390-15"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-3709"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61924-1"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67176-0"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182009991715"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2010.03.001"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2009.10.007"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2010.03.005"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.8.3497"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0503386102"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2007.061033"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2010.03.002"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1159\/000180268"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2613.2008.00622.x"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006267"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1286-4579(02)01541-1"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1002-05.2005"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1021\/pr300562m"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)91437-X"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2990.1999.00188.x"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000080203"},{"key":"e_1_3_3_24_2","first-page":"1121","article-title":"Early microvascular changes in murine cerebral malaria detected in retinal wholemounts","volume":"140","author":"Chan-Ling T","year":"1992","unstructured":"Chan-Ling T, Neill AL, Hunt NH. 1992. Early microvascular changes in murine cerebral malaria detected in retinal wholemounts. Am J Pathol 140:1121\u20131130.","journal-title":"Am J Pathol"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2005.12.005"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.12.7341-7348.2001"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.11.6369"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01747"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI133474"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.7.2502-2509.2004"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2016.08.017"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2017.08.025"},{"key":"e_1_3_3_33_2","first-page":"1580","article-title":"Preclinical development and clinical use of perillyl alcohol for chemoprevention and cancer therapy","volume":"5","author":"Chen TC","year":"2015","unstructured":"Chen TC, Da Fonseca CO, Sch\u00f6nthal AH. 2015. Preclinical development and clinical use of perillyl alcohol for chemoprevention and cancer therapy. Am J Cancer Res 5:1580\u20131593.","journal-title":"Am J Cancer Res"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0020204"},{"key":"e_1_3_3_35_2","first-page":"390","article-title":"Phase I clinical and pharmacokinetic study of perillyl alcohol administered four times a day","volume":"6","author":"Ripple GH","year":"2000","unstructured":"Ripple GH, Gould MN, Arzoomanian RZ, Alberti D, Feierabend C, Simon K, Binger K, Tutsch KD, Pomplun M, Wahamaki A, Marnocha R, Wilding G, Bailey HH. 2000. Phase I clinical and pharmacokinetic study of perillyl alcohol administered four times a day. Clin Cancer Rese 6:390\u2013396.","journal-title":"Clin Cancer Rese"},{"key":"e_1_3_3_36_2","first-page":"3071","article-title":"Phase I pharmacokinetic trial of perillyl alcohol (NSC 641066) in patients with refractory solid malignancies","volume":"6","author":"Hudes GR","year":"2000","unstructured":"Hudes GR, Szarka CE, Adams A, Ranganathan S, McCauley RA, Weiner LM, Langer CJ, Litwin S, Yeslow G, Halberr T, Qian M, Gallo JM. 2000. Phase I pharmacokinetic trial of perillyl alcohol (NSC 641066) in patients with refractory solid malignancies. Clin Cancer Rese 6:3071\u20133080.","journal-title":"Clin Cancer Rese"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-003-0684-y"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surneu.2007.07.040"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.03100"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0020-7519(99)00049-1"},{"key":"e_1_3_3_41_2","first-page":"1057","article-title":"An immunohistochemical study of the pathology of fatal malaria evidence for widespread endothelial activation and a potential role for intercellular adhesion molecule-1 in cerebral sequestration","volume":"145","author":"Turner GDH","year":"1994","unstructured":"Turner GDH, Morrison H, Jones M, Davis TME, Looareesuwan S, Buley ID, Gatter KC, Newbold C, Pukritayakamee S, Nagachinta B, White NJ, Berendt AR. 1994. An immunohistochemical study of the pathology of fatal malaria evidence for widespread endothelial activation and a potential role for intercellular adhesion molecule-1 in cerebral sequestration. Am J Pathol 145:1057\u20131069.","journal-title":"Am J Pathol"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-017-0945-y"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2017.09.009"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1286-4579(99)80513-9"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jir058"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-8-66"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00830"},{"key":"e_1_3_3_48_2","first-page":"136","article-title":"Immunological aspects of cerebral lesions in murine malaria","volume":"75","author":"Curfs JH","year":"1989","unstructured":"Curfs JH, Schetters TP, Hermsen CC, Jerusalem CR, van Zon AA, Eling WM. 1989. Immunological aspects of cerebral lesions in murine malaria. Clin Exp Immunol 75:136\u2013140.","journal-title":"Clin Exp Immunol"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2013.11.106"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.2174\/18715230113126660021"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2007.07.020"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2014.11.006"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3835(95)03747-k"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00005-008-0027-0"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)47425-5"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.01660"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0013124"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2015.03.030"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.6062"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-015-1476-6"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2015.08.020"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.4103\/jomfp.JOMFP_234_16"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2018.03.037"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0096801"},{"key":"e_1_3_3_66_2","volume-title":"ImageJ.","author":"Rasband WS","year":"1997","unstructured":"Rasband WS. 1997. ImageJ. U.S. National Institutes of Health, Bethesda, Maryland."}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00004-21","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00004-21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T21:57:35Z","timestamp":1645480655000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.00004-21"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,19]]},"references-count":65,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,4,19]]}},"alternative-id":["10.1128\/AAC.00004-21"],"URL":"https:\/\/doi.org\/10.1128\/aac.00004-21","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"type":"print","value":"0066-4804"},{"type":"electronic","value":"1098-6596"}],"subject":[],"published":{"date-parts":[[2021,4,19]]},"assertion":[{"value":"2021-01-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00004-21"}}