{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T07:00:35Z","timestamp":1789801235815,"version":"4.0.1"},"reference-count":56,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP20ak0101118h0002, JP23gm1610012h0001, JP22ama121039, JP23ama121039, JP22ama121053"],"award-info":[{"award-number":["JP20ak0101118h0002, JP23gm1610012h0001, JP22ama121039, JP23ama121039, JP22ama121053"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP21H03622, JP22K19416, JP25H01077"],"award-info":[{"award-number":["JP21H03622, JP22K19416, JP25H01077"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","award":["JPMJSP2119"],"award-info":[{"award-number":["JPMJSP2119"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","award":["ST211004JO"],"award-info":[{"award-number":["ST211004JO"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2026,8,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      Large-scale genomic studies have advanced our understanding of the global dissemination of antimicrobial-resistant (AMR) bacteria, yet most have been limited by inconsistent sampling periods, heterogeneous geographic coverage, and weak epidemiological linkages among isolates. Consequently, the fine-scale processes underlying the establishment and maintenance of AMR pandemics remain unclear. To address these limitations, we established a rigorously controlled community- and household-integrated One Health framework that incorporates human, animal, and environmental reservoirs within a single urban area and unified sampling period, focusing on the pandemic fluoroquinolone-resistant (FQ-R)\n                      <jats:italic toggle=\"yes\">Escherichia coli<\/jats:italic>\n                      sequence type (ST) 131. Using this model, we analyzed FQ-R\n                      <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                      isolates collected from humans, companion animals, sewage, and livestock in the Sapporo area, Japan, during 2021\u20132022. Among 2,358\n                      <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                      isolates, 235 FQ-R isolates, including 88 ST131 isolates, underwent genomic analyses based on pan-, accessory-, and core genome data. These analyses revealed high clonal diversity but clear population structuring within ST131, with several subclusters shared between human and companion animal sources. High-resolution core genome SNP analysis delineated community-level transmission dynamics, demonstrating ST131 carriage among healthy humans and suggesting asymptomatic human-to-human spread and household-level human\u2013companion animal transmission. These carriage isolates harbored multiple AMR genes and virulence factors and exhibited high genetic similarity to clinical isolates, indicating potential contributions to hospital-associated infections. Phylogenetic integration with international ST131 genomes demonstrated that transmission events in Sapporo are embedded within the broader global expansion of ST131. This study provides a scalable model for resolving local-to-global AMR dissemination and underscores the need for community- and household-level interventions within a One Health framework.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/aac.00007-26","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T13:00:45Z","timestamp":1782219645000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":1,"title":["A community-based One Health approach to the pandemic dynamics of\n                    <i>Escherichia coli<\/i>\n                    ST131"],"prefix":"10.1128","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-4071-2555","authenticated-orcid":true,"given":"Aiko","family":"Maeda","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02e16g702","id-type":"ROR","asserted-by":"publisher"}],"name":"Laboratory of Veterinary Hygiene, Faculty of Veterinary Medicine, Hokkaido University","place":["Sapporo, Japan"]},{"id":[{"id":"https:\/\/ror.org\/02e16g702","id-type":"ROR","asserted-by":"publisher"}],"name":"Graduate School of Infectious Diseases, Hokkaido University","place":["Sapporo, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7223-1623","authenticated-orcid":true,"given":"Toyotaka","family":"Sato","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02e16g702","id-type":"ROR","asserted-by":"publisher"}],"name":"Laboratory of Veterinary Hygiene, Faculty of Veterinary Medicine, Hokkaido University","place":["Sapporo, Japan"]},{"id":[{"id":"https:\/\/ror.org\/02e16g702","id-type":"ROR","asserted-by":"publisher"}],"name":"Graduate School of Infectious Diseases, Hokkaido University","place":["Sapporo, Japan"]},{"id":[{"id":"https:\/\/ror.org\/02e16g702","id-type":"ROR","asserted-by":"publisher"}],"name":"One Health Research Center, Hokkaido 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