{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T01:44:48Z","timestamp":1790905488576,"version":"4.1.0"},"reference-count":16,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>We evaluated the in vivo efficacy of three \u03b2-cyclodextrin derivatives that block the anthrax protective antigen pore. These compounds were at least 15-fold more potent than previously described \u03b2-cyclodextrins in protecting against anthrax lethal toxin in a rat model. One of the drugs was shown to protect mice from bacterial infection.<\/jats:p>","DOI":"10.1128\/aac.00009-08","type":"journal-article","created":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:46:09Z","timestamp":1207010769000},"page":"2239-2241","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":33,"title":["In Vivo Efficacy of \u03b2-Cyclodextrin Derivatives against Anthrax Lethal Toxin"],"prefix":"10.1128","volume":"52","author":[{"given":"Mahtab","family":"Moayeri","sequence":"first","affiliation":[{"name":"Bacterial Toxins and Therapeutics Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanisha M.","family":"Robinson","sequence":"additional","affiliation":[{"name":"Innovative Biologics, Inc., 13455 Sunrise Valley Dr., Suite 200, Herndon, Virginia 20171"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen H.","family":"Leppla","sequence":"additional","affiliation":[{"name":"Bacterial Toxins and Therapeutics Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir A.","family":"Karginov","sequence":"additional","affiliation":[{"name":"Innovative Biologics, Inc., 13455 Sunrise Valley Dr., Suite 200, Herndon, Virginia 20171"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00261-07"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1086\/500148"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.45.3.761-767.1984"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)61218-7"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0264-410X(95)00139-R"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0507488102"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00693-06"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0928-8244(03)00302-X"},{"key":"e_1_3_2_10_2","first-page":"323","year":"2006","unstructured":"Leppla, S. H. 2006. Bacillus anthracis toxins, p. 323-347. In J. E. Alouf and M. R. Popoff (ed.), The comprehensive sourcebook of bacterial protein toxins. Academic Press, Burlington, MA.","journal-title":"The comprehensive sourcebook of bacterial protein toxins"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI17991"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.8.4439-4447.2004"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.74.2.1016-1024.2006"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(01)00234-1"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.9.5978-5987.2005"},{"key":"e_1_3_2_16_2","first-page":"964","volume":"16","year":"2005","unstructured":"Xiong, Y., J. Wiltsie, A. Woods, J. Guo, J. V. Pivnichny, W. Tang, A. Bansal, R. T. Cummings, B. R. Cunningham, A. M. Friedlander, C. M. Douglas, S. P. Salowe, D. M. Zaller, E. M. Scolnick, D. M. Schmatz, K. Bartizal, J. D. Hermes, M. Maccoss, and K. T. Chapman. 2005. The discovery of a potent and selective lethal factor inhibitor for adjunct therapy of anthrax infection. Bioorg. Med. Chem. Lett.16:964-968.","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.75.103004.142728"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00009-08","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00009-08","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T19:42:45Z","timestamp":1645472565000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.00009-08"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6]]},"references-count":16,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008,6]]}},"alternative-id":["10.1128\/AAC.00009-08"],"URL":"https:\/\/doi.org\/10.1128\/aac.00009-08","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,6]]},"assertion":[{"value":"2008-01-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2008-03-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2008-06-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}