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In this report, the antiviral efficacy of ST-246 in treatment of nonhuman primates infected with variola virus or monkeypox virus was assessed. The data indicate that oral dosing once per day with ST-246 protects animals from poxvirus disease, as measured by reductions in viral load and numbers of lesions and enhancement of survival.<\/jats:p>","DOI":"10.1128\/aac.00021-09","type":"journal-article","created":{"date-parts":[[2009,4,7]],"date-time":"2009-04-07T01:07:24Z","timestamp":1239066444000},"page":"2620-2625","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":170,"title":["Nonhuman Primates Are Protected from Smallpox Virus or Monkeypox Virus Challenges by the Antiviral Drug ST-246"],"prefix":"10.1128","volume":"53","author":[{"given":"John","family":"Huggins","sequence":"first","affiliation":[{"name":"U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur","family":"Goff","sequence":"additional","affiliation":[{"name":"U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Hensley","sequence":"additional","affiliation":[{"name":"U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Mucker","sequence":"additional","affiliation":[{"name":"U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josh","family":"Shamblin","sequence":"additional","affiliation":[{"name":"U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carly","family":"Wlazlowski","sequence":"additional","affiliation":[{"name":"U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Johnson","sequence":"additional","affiliation":[{"name":"U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Chapman","sequence":"additional","affiliation":[{"name":"U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Larsen","sequence":"additional","affiliation":[{"name":"U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Twenhafel","sequence":"additional","affiliation":[{"name":"U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Karem","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inger K.","family":"Damon","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chelsea M.","family":"Byrd","sequence":"additional","affiliation":[{"name":"SIGA Technologies, Corvallis, Oregon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tove' C.","family":"Bolken","sequence":"additional","affiliation":[{"name":"SIGA Technologies, Corvallis, Oregon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Jordan","sequence":"additional","affiliation":[{"name":"SIGA Technologies, Corvallis, Oregon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Hruby","sequence":"additional","affiliation":[{"name":"SIGA Technologies, Corvallis, Oregon"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","first-page":"642","volume":"52","year":"2003","unstructured":"Centers for Disease Control and Prevention. 2003. 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