{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:30:15Z","timestamp":1791354615062,"version":"4.3.1"},"reference-count":35,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2011,6]]},"abstract":"ABSTRACT<\/jats:title>\n \n Two\n bla<\/jats:italic>\n OXA-48<\/jats:sub>\n -like-positive isolates (\n Klebsiella pneumoniae<\/jats:named-content>\n and\n Enterobacter cloacae<\/jats:named-content>\n ) were recovered in Argentina in 2008 as part of a large-scale survey focused on multidrug resistance in\n Enterobacteriaceae<\/jats:named-content>\n . In both cases, sequencing identified \u03b2-lactamase OXA-163, differing from OXA-48 by a single amino substitution and a 4-amino-acid deletion. OXA-163 hydrolyzed penicillins, ceftazidime, and cefotaxime, whereas OXA-48 did not. However, OXA-163 had a much lower ability to hydrolyze carbapenems than OXA-48, therefore barely being considered a carbapenemase. In both isolates, the\n bla<\/jats:italic>\n OXA-163<\/jats:sub>\n gene was located on plasmids that differed in structure and size. However, a detailed genetic analysis revealed a similar genetic context in those isolates, with the\n bla<\/jats:italic>\n OXA-163<\/jats:sub>\n gene being bracketed by novel transposase genes, making this genetic environment different from that reported for the\n bla<\/jats:italic>\n OXA-48<\/jats:sub>\n gene. This study identified the first class D \u03b2-lactamase compromising both extended-spectrum cephalosporin and carbapenem activities.\n <\/jats:p>","DOI":"10.1128\/aac.00022-11","type":"journal-article","created":{"date-parts":[[2011,3,22]],"date-time":"2011-03-22T04:57:09Z","timestamp":1300769829000},"page":"2546-2551","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":154,"title":["OXA-163, an OXA-48-Related Class D \u03b2-Lactamase with Extended Activity Toward Expanded-Spectrum Cephalosporins"],"prefix":"10.1128","volume":"55","author":[{"given":"Laurent","family":"Poirel","sequence":"first","affiliation":[{"name":"Service de Bact\u00e9riologie-Virologie, INSERM U914, Emerging Resistance to Antibiotics, H\u00f4pital de Bic\u00eatre, Assistance Publique\/H\u00f4pitaux de Paris, Facult\u00e9 de M\u00e9decine Paris Sud, Le Kremlin Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Castanheira","sequence":"additional","affiliation":[{"name":"JMI Laboratories, North Liberty, Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Am\u00e9lie","family":"Carr\u00ebr","sequence":"additional","affiliation":[{"name":"Service de Bact\u00e9riologie-Virologie, INSERM U914, Emerging Resistance to Antibiotics, H\u00f4pital de Bic\u00eatre, Assistance Publique\/H\u00f4pitaux de Paris, Facult\u00e9 de M\u00e9decine Paris Sud, Le Kremlin Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla Parada","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Service de Bact\u00e9riologie-Virologie, INSERM U914, Emerging Resistance to Antibiotics, H\u00f4pital de Bic\u00eatre, Assistance Publique\/H\u00f4pitaux de Paris, Facult\u00e9 de M\u00e9decine Paris Sud, Le Kremlin Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald N.","family":"Jones","sequence":"additional","affiliation":[{"name":"JMI Laboratories, North Liberty, Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorgelina","family":"Smayevsky","sequence":"additional","affiliation":[{"name":"Laboratorio de Bacteriolog\u00eda, Micolog\u00eda, y Parasitolog\u00eda, Centro de Educaci\u00f3n M\u00e9dica e Investigaciones Cl\u00ednicas Norberto Quirno CEMIC, Ciudad Aut\u00f3noma de Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrice","family":"Nordmann","sequence":"additional","affiliation":[{"name":"Service de Bact\u00e9riologie-Virologie, INSERM U914, Emerging Resistance to Antibiotics, H\u00f4pital de Bic\u00eatre, Assistance Publique\/H\u00f4pitaux de Paris, Facult\u00e9 de M\u00e9decine Paris Sud, Le Kremlin Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1159\/000118661"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00375-06"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1179\/136485910X12743554760108"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mimet.2005.03.018"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01672-07"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01312-09"},{"key":"e_1_3_2_8_2","volume-title":"CLSI M100-S20U","author":"Clinical and Laboratory Standards Institute","year":"2010","unstructured":"Clinical and Laboratory Standards Institute. 2010. 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