{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T20:31:09Z","timestamp":1773001869675,"version":"3.50.1"},"reference-count":24,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T00:00:00Z","timestamp":1251763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2009,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>LBM415 is an antibacterial agent belonging to the peptide deformylase inhibitor class of compounds. It has previously been shown to demonstrate good activity in vitro against a range of pathogens. In this study, the in vivo efficacy of LBM415 was evaluated in various mouse infection models. We investigated activity against a systemic infection model caused by intraperitoneal inoculation of<jats:italic>Staphylococcus aureus<\/jats:italic>(methicillin [meticillin] susceptible [MSSA] and methicillin resistant [MRSA]) and<jats:italic>Streptococcus pneumoniae<\/jats:italic>(penicillin susceptible [PSSP] and multidrug resistant [MDRSP]), a thigh infection model caused by intramuscular injection of MRSA, and a lung infection produced by intranasal inoculation of PSSP. In the systemic MSSA and MRSA infections, LBM415 was equivalent to linezolid and vancomycin. In the systemic PSSP infection, LBM415 was equivalent to linezolid, whereas against systemic MDRSP infection, the LBM415 50% effective dose (ED<jats:sub>50<\/jats:sub>) was 4.8 mg\/kg (dosed subcutaneously) and 36.6 mg\/kg (dosed orally), compared to 13.2 mg\/kg for telithromycin and &gt;60 mg\/kg for penicillin V and clarithromycin. In the MRSA thigh infection, LBM415 significantly reduced thigh bacterial levels compared to those of untreated mice, with levels similar to those after treatment with linezolid at the same dose levels. In the pneumonia model, the ED<jats:sub>50<\/jats:sub>to reduce the bacterial lung burden by &gt;4 log<jats:sub>10<\/jats:sub>in 50% of treated animals was 23.3 mg\/kg for LBM415, whereas moxifloxacin showed an ED<jats:sub>50<\/jats:sub>of 14.3 mg\/kg. In summary, LBM415 showed in vivo efficacy in sepsis and specific organ infection models irrespective of resistance to other antibiotics. Results suggest the potential of peptide deformylase inhibitors as a novel class of therapeutic agents against antibiotic-resistant pathogens.<\/jats:p>","DOI":"10.1128\/aac.00026-09","type":"journal-article","created":{"date-parts":[[2009,7,14]],"date-time":"2009-07-14T01:30:38Z","timestamp":1247535038000},"page":"3777-3781","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":21,"title":["In Vivo Characterization of the Peptide Deformylase Inhibitor LBM415 in Murine Infection Models"],"prefix":"10.1128","volume":"53","author":[{"given":"Colin S.","family":"Osborne","sequence":"first","affiliation":[{"name":"Infectious Diseases, Novartis Institutes for BioMedical Research Inc., Cambridge, Massachusetts 02139"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg","family":"Neckermann","sequence":"additional","affiliation":[{"name":"Infectious Diseases, Novartis Institutes for BioMedical Research Inc., Cambridge, Massachusetts 02139"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evelin","family":"Fischer","sequence":"additional","affiliation":[{"name":"Infectious Diseases, Novartis Institutes for BioMedical Research Inc., Cambridge, Massachusetts 02139"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Pecanka","sequence":"additional","affiliation":[{"name":"Infectious Diseases, Novartis Institutes for BioMedical Research Inc., Cambridge, Massachusetts 02139"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donghui","family":"Yu","sequence":"additional","affiliation":[{"name":"Infectious Diseases, Novartis Institutes for BioMedical Research Inc., Cambridge, Massachusetts 02139"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kari","family":"Manni","sequence":"additional","affiliation":[{"name":"Infectious Diseases, Novartis Institutes for BioMedical Research Inc., Cambridge, Massachusetts 02139"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Goldovitz","sequence":"additional","affiliation":[{"name":"Infectious Diseases, Novartis Institutes for BioMedical Research Inc., Cambridge, Massachusetts 02139"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerri","family":"Amaral","sequence":"additional","affiliation":[{"name":"Infectious Diseases, Novartis Institutes for BioMedical Research Inc., Cambridge, Massachusetts 02139"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JoAnn","family":"Dzink-Fox","sequence":"additional","affiliation":[{"name":"Infectious Diseases, Novartis Institutes for BioMedical Research Inc., Cambridge, Massachusetts 02139"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil S.","family":"Ryder","sequence":"additional","affiliation":[{"name":"Infectious Diseases, Novartis Institutes for BioMedical Research Inc., Cambridge, Massachusetts 02139"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.1.80-85.2004"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00106-06"},{"key":"e_1_3_1_4_2","doi-asserted-by":"crossref","first-page":"i23","DOI":"10.1093\/jac\/dkh311","volume":"54","year":"2004","unstructured":"Brown, S. 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