{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T16:07:02Z","timestamp":1770739622372,"version":"3.49.0"},"reference-count":18,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Testing of\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Cryptococcus neoformans<\/jats:named-content>\n            for susceptibility to antifungal drugs by standard microtiter methods has not been shown to correlate with clinical outcomes. This report describes a modified quantitative broth macrodilution susceptibility method showing a correlation with both the patient's quantitative biological response in the cerebrospinal fluid (CSF) and the survival of 85 patients treated with amphotericin B (AMB). The Spearman rank correlation between the quantitative\n            <jats:italic>in vitro<\/jats:italic>\n            measure of susceptibility and the quantitative measure of the number of organisms in the patient's CSF was 0.37 (\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.01; 95% confidence interval [95% CI], 0.20, 0.60) for the first susceptibility test replicate and 0.46 (\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.001; 95% CI, 0.21, 0.62) for the second susceptibility test replicate. The median\n            <jats:italic>in vitro<\/jats:italic>\n            estimated response (defined as the fungal burden after AMB treatment) at 1.5 mg\/liter AMB for patients alive at day 14 was 5 CFU (95% CI, 3, 8), compared to 57 CFU (95% CI, 4, 832) for those who died before day 14. These exploratory results suggest that patients whose isolates show a quantitative\n            <jats:italic>in vitro<\/jats:italic>\n            susceptibility response below 10 CFU\/ml were more likely to survive beyond day 14.\n          <\/jats:p>","DOI":"10.1128\/aac.00034-11","type":"journal-article","created":{"date-parts":[[2011,9,27]],"date-time":"2011-09-27T03:50:46Z","timestamp":1317095446000},"page":"5624-5630","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":15,"title":["Correlation of Susceptibility of Cryptococcus neoformans to Amphotericin B with Clinical Outcome"],"prefix":"10.1128","volume":"55","author":[{"given":"R. A.","family":"Larsen","sequence":"first","affiliation":[{"name":"Department of Medicine (Infectious Diseases), University of Southern California, Los Angeles, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Bauer","sequence":"additional","affiliation":[{"name":"Department of Medicine (Infectious Diseases), University of Southern California, Los Angeles, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Pitisuttithum","sequence":"additional","affiliation":[{"name":"Faculty of Tropical Medicine, Mahidol University, Bangkok"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Department of Medicine (Infectious Diseases), University of Southern California, Los Angeles, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Tansuphaswadikul","sequence":"additional","affiliation":[{"name":"Bamrasnardura Hospital, Communicable Disease Control Department, Nonthaburi, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Wuthiekanun","sequence":"additional","affiliation":[{"name":"Faculty of Tropical Medicine, Mahidol University, Bangkok"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. J.","family":"Peacock","sequence":"additional","affiliation":[{"name":"Faculty of Tropical Medicine, Mahidol University, Bangkok"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. J. H.","family":"Simpson","sequence":"additional","affiliation":[{"name":"Faculty of Tropical Medicine, Mahidol University, Bangkok"},{"name":"Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Churchill Hospital, Oxford, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. W.","family":"Fothergill","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Texas Health Science Center of San Antonio, San Antonio, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. G.","family":"Rinaldi","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Texas Health Science Center of San Antonio, San Antonio, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Bustamante","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Tropical Alexander Von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. M.","family":"Thomas","sequence":"additional","affiliation":[{"name":"University of Northern Colorado, Greeley, Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Altomstone","sequence":"additional","affiliation":[{"name":"Department of Medicine (Infectious Diseases), University of Southern California, Los Angeles, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. P. J.","family":"Day","sequence":"additional","affiliation":[{"name":"Faculty of Tropical Medicine, Mahidol University, Bangkok"},{"name":"Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Churchill Hospital, Oxford, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. J.","family":"White","sequence":"additional","affiliation":[{"name":"Faculty of Tropical Medicine, Mahidol University, Bangkok"},{"name":"Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Churchill Hospital, Oxford, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1086\/588792"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16301-0"},{"key":"e_1_3_2_4_2","volume-title":"Hobart","author":"Cleveland W. S.","year":"1993","unstructured":"ClevelandW. S. 1993. 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New York NY."}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00034-11","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00034-11","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T23:23:13Z","timestamp":1645485793000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.00034-11"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12]]},"references-count":18,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["10.1128\/AAC.00034-11"],"URL":"https:\/\/doi.org\/10.1128\/aac.00034-11","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12]]},"assertion":[{"value":"2011-01-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-09-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-11-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}