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Here, we present evidence that drugs designed to inhibit mammalian exosome production exhibit similar effects on\n              <jats:italic toggle=\"yes\">C. albicans<\/jats:italic>\n              extracellular vesicles\n              <jats:italic toggle=\"yes\">,<\/jats:italic>\n              ultimately eliminating biofilm matrix assembly. We find that vesicle reduction renders biofilm communities susceptible to the antifungal fluconazole. Our findings argue that vesicle trafficking pathways represent a promising target to optimize for recalcitrant fungal biofilms.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1128\/aac.00045-25","type":"journal-article","created":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T14:33:52Z","timestamp":1742999632000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":4,"title":["Vesicle inhibition reduces\n            <i>Candida<\/i>\n            biofilm resistance"],"prefix":"10.1128","volume":"69","author":[{"given":"Min-Ju","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Wisconsin-Madison","place":["Madison, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6343-1500","authenticated-orcid":true,"given":"Robert","family":"Zarnowski","sequence":"additional","affiliation":[{"name":"Department of Medicine, 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