{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T14:31:43Z","timestamp":1718289103781},"reference-count":22,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2010,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The histopathology of clinical isolates of\n            <jats:italic>Scedosporium apiospermum<\/jats:italic>\n            ,\n            <jats:italic>Scedosporium boydii<\/jats:italic>\n            , and\n            <jats:italic>Scedosporium aurantiacum<\/jats:italic>\n            in immunosuppressed mice was evaluated. The organs most affected were the brain, kidneys, and spleen.\n            <jats:italic>S. aurantiacum<\/jats:italic>\n            produced more tissue damage than the other two species. Amphotericin B (AMB) was ineffective in the treatment of murine infections caused by such isolates, and posaconazole and voriconazole showed efficacy that correlated with the\n            <jats:italic>in vitro<\/jats:italic>\n            susceptibility data.\n          <\/jats:p>","DOI":"10.1128\/aac.00046-10","type":"journal-article","created":{"date-parts":[[2010,6,15]],"date-time":"2010-06-15T04:11:20Z","timestamp":1276575080000},"page":"3980-3984","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":21,"title":["Experimental Murine Scedosporiosis: Histopathology and Azole Treatment"],"prefix":"10.1128","volume":"54","author":[{"given":"M. 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