{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:58:17Z","timestamp":1790747897107,"version":"4.1.0"},"reference-count":19,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Vibrio parahaemolyticus<\/jats:named-content>\n            is commonly resistant to ampicillin, yet the mechanisms underlying this phenomenon are not clear. In this study, a novel class A carbenicillin-hydrolyzing \u03b2-lactamase (CARB) family of \u03b2-lactamases,\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>CARB-17<\/jats:sub>\n            , was identified and found to be responsible for the intrinsic penicillin resistance in\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">V. parahaemolyticus<\/jats:named-content>\n            . Importantly,\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>CARB-17<\/jats:sub>\n            -like genes were present in all 293\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">V. parahaemolyticus<\/jats:named-content>\n            genome sequences available in GenBank and detectable in all 91\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">V. parahaemolyticus<\/jats:named-content>\n            food isolates, further confirming the intrinsic nature of this gene.\n          <\/jats:p>","DOI":"10.1128\/aac.00047-15","type":"journal-article","created":{"date-parts":[[2015,3,24]],"date-time":"2015-03-24T02:32:47Z","timestamp":1427164367000},"page":"3593-3595","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":74,"title":["CARB-17 Family of \u03b2-Lactamases Mediates Intrinsic Resistance to Penicillins in Vibrio parahaemolyticus"],"prefix":"10.1128","volume":"59","author":[{"given":"Jiachi","family":"Chiou","sequence":"first","affiliation":[{"name":"Shenzhen Key Lab for Food Biological Safety Control, Food Safety and Technology Research Center, Hong Kong PolyU Shen Zhen Research Institute, Shenzhen, People's Republic of China"},{"name":"State Key Lab of Chirosciences, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruichao","family":"Li","sequence":"additional","affiliation":[{"name":"Shenzhen Key Lab for Food Biological Safety Control, Food Safety and Technology Research Center, Hong Kong PolyU Shen Zhen Research Institute, Shenzhen, People's Republic of China"},{"name":"State Key Lab of Chirosciences, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Chen","sequence":"additional","affiliation":[{"name":"Shenzhen Key Lab for Food Biological Safety Control, Food Safety and Technology Research Center, Hong Kong PolyU Shen Zhen Research Institute, Shenzhen, People's Republic of China"},{"name":"State Key Lab of Chirosciences, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","first-page":"114","article-title":"Clinical aspects of acute intestinal infection caused by Vibrio parahaemolyticus","volume":"6","author":"Shevchuk VB","year":"1986","unstructured":"Shevchuk VB, Gebesh VV, Alekseenko VV, Dobroshtan EV, Padchenko AG. 1986. Clinical aspects of acute intestinal infection caused by Vibrio parahaemolyticus. Vrach Delo 6:114\u2013116. (In Russian.)","journal-title":"Vrach Delo"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2008.08.008"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-011-1162-9"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/genomeA.00300-13"},{"key":"e_1_3_3_6_2","volume-title":"CLSI M100-S23","author":"Clinical and Laboratory Standards Institute","year":"2013","unstructured":"Clinical and Laboratory Standards Institute. 2013. Performance standards for antimicrobial susceptibility testing. CLSI M100-S23. 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