{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T21:24:55Z","timestamp":1769721895984,"version":"3.49.0"},"reference-count":19,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            We evaluated the combination of posaconazole with amphotericin B\n            <jats:italic>in vitro<\/jats:italic>\n            and in a murine model of systemic infections caused by\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Sporothrix brasiliensis<\/jats:named-content>\n            and\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Sporothrix schenckii<\/jats:named-content>\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">sensu stricto<\/jats:named-content>\n            .\n            <jats:italic>In vitro<\/jats:italic>\n            data demonstrated a synergistic effect, and although posaconazole alone was effective against sporotrichosis, efficacy in terms of survival and burden reduction was increased with the combination. This combination might be an option against disseminated sporotrichosis, especially when itraconazole or amphotericin B at optimal doses are contraindicated.\n          <\/jats:p>","DOI":"10.1128\/aac.00052-15","type":"journal-article","created":{"date-parts":[[2015,5,27]],"date-time":"2015-05-27T15:24:53Z","timestamp":1432740293000},"page":"5018-5021","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":17,"title":["<i>In Vitro<\/i>\n            and\n            <i>In Vivo<\/i>\n            Efficacy of Amphotericin B Combined with Posaconazole against Experimental Disseminated Sporotrichosis"],"prefix":"10.1128","volume":"59","author":[{"given":"D\u00e9bora Nunes","family":"Mario","sequence":"first","affiliation":[{"name":"Microbiology Unit, Medical School, Universitat Rovira i Virgili, IISPV, Reus, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josep","family":"Guarro","sequence":"additional","affiliation":[{"name":"Microbiology Unit, Medical School, Universitat Rovira i Virgili, IISPV, Reus, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janio Morais","family":"Santurio","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Parasitology, Universidade Federal de Santa Maria, Santa Maria, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sydney Hartz","family":"Alves","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Parasitology, Universidade Federal de Santa Maria, Santa Maria, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Capilla","sequence":"additional","affiliation":[{"name":"Microbiology Unit, Medical School, Universitat Rovira i Virgili, IISPV, Reus, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/bcr.10.2010.3404"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2011.05.005"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00808-07"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13225-013-0220-2"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.3109\/13693786.2011.584074"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.3109\/13693786.2011.596288"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1086\/522765"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-14-219"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.05376-11"},{"key":"e_1_3_2_11_2","volume-title":"Reference method for broth dilution antifungal susceptibility testing of filamentous fungi; approved standard","author":"Clinical and Laboratory Standards Institute","year":"2008","unstructured":"Clinical and Laboratory Standards Institute. 2008. Reference method for broth dilution antifungal susceptibility testing of filamentous fungi; approved standard, 2nd ed. CLSI document M38-A2. Clinical and Laboratory Standards Institute, Wayne, PA.","edition":"2"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.3.970-978.2004"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2009.02824.x"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1130-1406(07)70010-4"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2004.07.001"},{"key":"e_1_3_2_16_2","first-page":"253","article-title":"Fatal sporotrichosis","volume":"78","author":"Yelverton CB","year":"2006","unstructured":"Yelverton CB, Stetson CL, Bang RH, Clark JW, Butler DF. 2006. Fatal sporotrichosis. 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