{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T15:42:09Z","timestamp":1784302929116,"version":"3.55.0"},"reference-count":24,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Adequate penetration to the infection\/colonization site is crucial to attain optimal efficacy of posaconazole against\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Aspergillus fumigatus<\/jats:named-content>\n            diseases. We evaluated posaconazole exposure in pulmonary epithelial lining fluid (ELF) in a murine model of invasive pulmonary aspergillosis. The posaconazole exposure (area under the plasma concentration-time curve from time zero to 24 h postinfusion [AUC\n            <jats:sub>0\u201324<\/jats:sub>\n            ]) in ELF was 20% to 31% of that in plasma for total drug after the third dose, and the relationship between plasma and ELF exposure was linear (\n            <jats:italic>r<\/jats:italic>\n            <jats:sup>2<\/jats:sup>\n            = 0.97,\n            <jats:italic>P<\/jats:italic>\n            = 0.016).\n          <\/jats:p>","DOI":"10.1128\/aac.00053-14","type":"journal-article","created":{"date-parts":[[2014,2,25]],"date-time":"2014-02-25T02:39:52Z","timestamp":1393295992000},"page":"2964-2967","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":16,"title":["Intrapulmonary Posaconazole Penetration at the Infection Site in an Immunosuppressed Murine Model of Invasive Pulmonary Aspergillosis Receiving Oral Prophylactic Regimens"],"prefix":"10.1128","volume":"58","author":[{"given":"Seyedmojtaba","family":"Seyedmousavi","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology, Radboudumc, Nijmegen, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger J. M.","family":"Br\u00fcggemann","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Radboudumc, Nijmegen, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willem J. G.","family":"Melchers","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Radboudumc, Nijmegen, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul E.","family":"Verweij","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Radboudumc, Nijmegen, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan W.","family":"Mouton","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Radboudumc, Nijmegen, the Netherlands"},{"name":"Department of Medical Microbiology and Infectious Diseases, Erasmus MC, Rotterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","volume-title":"European public assessment report (EPAR) for Noxafil","author":"EMA","year":"2012","unstructured":"EMA. 2012. European public assessment report (EPAR) for Noxafil, 06\/09\/2012 ed. 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EUCAST definitive document E.DEF 9.1: method for the determination of broth dilution minimum inhibitory concentrations of antifungal agents for conidia forming moulds. Subcommittee on Antifungal Susceptibility Testing (AFST) of the ESCMID European Committee for Antimicrobial Susceptibility Testing (EUCAST). http:\/\/www.eucast.org\/fileadmin\/src\/media\/PDFs\/4ESCMID_Library\/3Publications\/EUCAST_Documents\/Other_Documents\/EUCAST_moulds_DEFINITIVE_document_V_ISO_April_08%20final.pdf."},{"key":"e_1_3_2_11_2","volume-title":"Final Prog. 53rd Intersci. Conf. Antimicrob. Agents Chemother","author":"Seyedmousavi S","year":"2013","unstructured":"SeyedmousaviSBr\u00fcggemannRJMMelchersWJGMoutonJWVerweijPE. 2013. Posaconazole prophylaxis in experimental azole-resistant invasive pulmonary aspergillosis, pos ter M-761. Final Prog. 53rd Intersci. Conf. Antimicrob. Agents Chemother."},{"key":"e_1_3_2_12_2","volume-title":"Final Prog. 52nd Intersci. Conf. Antimicrob. 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