{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:50:27Z","timestamp":1790707827549,"version":"4.1.0"},"reference-count":39,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            A total of 2,841 clinical isolates of\n            <jats:italic>Klebsiella pneumoniae<\/jats:italic>\n            from intra-abdominal infections worldwide were collected in the Study for Monitoring Antimicrobial Resistance Trends (SMART) during 2008 and 2009. Overall, 22.4% of isolates had extended-spectrum \u03b2-lactamases (ESBLs). The most active antibiotics among the 11 tested were imipenem, amikacin, and ertapenem, though even these, like all other comparators, were less consistently active against ESBL-positive isolates than against ESBL-negative isolates. Globally, 6.5% of isolates were ertapenem resistant based on the June 2010 clinical breakpoints published by the Clinical and Laboratory Standards Institute, with MICs of \u22651 \u03bcg\/ml. Molecular characterization of 43 isolates with ertapenem MICs of \u22654 \u03bcg\/ml showed that they variously produced CTX-M or SHV ESBLs combined with altered impermeability and\/or had KPC (\n            <jats:italic>n<\/jats:italic>\n            = 28), OXA-48 (\n            <jats:italic>n<\/jats:italic>\n            = 3), or VIM (\n            <jats:italic>n<\/jats:italic>\n            = 1) carbapenemases. Further monitoring of ertapenem susceptibility and molecular characterization of ertapenem-resistant isolates are needed.\n          <\/jats:p>","DOI":"10.1128\/aac.00070-11","type":"journal-article","created":{"date-parts":[[2011,6,14]],"date-time":"2011-06-14T17:44:05Z","timestamp":1308073445000},"page":"3917-3921","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":46,"title":["Susceptibility of\n            <i>Klebsiella pneumoniae<\/i>\n            Isolates from Intra-Abdominal Infections and Molecular Characterization of Ertapenem-Resistant Isolates"],"prefix":"10.1128","volume":"55","author":[{"given":"Stephen P.","family":"Hawser","sequence":"first","affiliation":[{"name":"IHMA Europe S\u00e0rl, 1066 Epalinges, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel K.","family":"Bouchillon","sequence":"additional","affiliation":[{"name":"International Health Management Associates, Inc., Schaumburg, Illinois 60173-3817"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Lascols","sequence":"additional","affiliation":[{"name":"International Health Management Associates, Inc., Schaumburg, Illinois 60173-3817"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meredith","family":"Hackel","sequence":"additional","affiliation":[{"name":"International Health Management Associates, Inc., Schaumburg, Illinois 60173-3817"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daryl J.","family":"Hoban","sequence":"additional","affiliation":[{"name":"International Health Management Associates, Inc., Schaumburg, Illinois 60173-3817"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert E.","family":"Badal","sequence":"additional","affiliation":[{"name":"International Health Management Associates, Inc., Schaumburg, Illinois 60173-3817"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Woodford","sequence":"additional","affiliation":[{"name":"Antibiotic Resistance Monitoring and Reference Laboratory, HPA Microbiology Services\u2014Colindale, London NW9 5EQ, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Livermore","sequence":"additional","affiliation":[{"name":"Antibiotic Resistance Monitoring and Reference Laboratory, HPA Microbiology Services\u2014Colindale, London NW9 5EQ, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(82)90594-3"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.7.3018-3020.2005"},{"key":"e_1_3_2_4_2","volume-title":"document M7-A7","author":"Clinical and Laboratory Standards Institute","year":"2008","unstructured":"Clinical and Laboratory Standards Institute. 2008. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically; approved standard, 7th ed., document M7-A7. Clinical and Laboratory Standards Institute, Wayne, PA.","edition":"7"},{"key":"e_1_3_2_5_2","unstructured":"Clinical and Laboratory Standards Institute. 2010. Performance standards for antimicrobial susceptibility testing document M100-S20. Clinical and Laboratory Standards Institute Wayne PA."},{"key":"e_1_3_2_6_2","unstructured":"Clinical and Laboratory Standards Institute. 2010. Performance standards for antimicrobial susceptibility testing document M100-S20-U. Clinical and Laboratory Standards Institute Wayne PA."},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkp029"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkl481"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkp327"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01690508"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01301-09"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01007-08"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1089\/sur.2009.057"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00265-10"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkq108"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01808-09"},{"key":"e_1_3_2_17_2","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.ijantimicag.2010.07.002","article-title":"Epidemiology and antimicrobial susceptibility profiles of aerobic and facultative Gram-negative bacilli isolated from patients with intra-abdominal infections in the Asia-Pacific region: 2008 results from SMART (Study for Monitoring Antimicrobial Resistance Trends)","volume":"36","author":"Hsueh P. R.","year":"2010","unstructured":"HsuehP. R. . 2010. Epidemiology and antimicrobial susceptibility profiles of aerobic and facultative Gram-negative bacilli isolated from patients with intra-abdominal infections in the Asia-Pacific region: 2008 results from SMART (Study for Monitoring Antimicrobial Resistance Trends). Int. J. Antimicrob. Agents 36:408\u2013414.","journal-title":"Int. J. Antimicrob. Agents"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1086\/501572"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(10)70143-2"},{"key":"e_1_3_2_20_2","first-page":"218","article-title":"The impact of carbapenemases on antimicrobial development and therapy","volume":"3","author":"Livermore D. M.","year":"2002","unstructured":"LivermoreD. M. 2002. The impact of carbapenemases on antimicrobial development and therapy. Curr. Opin. Invest. Drugs 3:218\u2013224.","journal-title":"Curr. Opin. Invest. Drugs"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkl483"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199111000-00001"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.4.1204-1214.2004"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00987-08"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(09)70054-4"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01690097"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.40.6.2153-2162.2002"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkp207"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkq190"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199011000-00004"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1086\/649554"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.4.879"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1086\/594129"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.18.2.306-325.2005"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1086\/501571"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dki412"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2006.11.020"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkn396"},{"key":"e_1_3_2_39_2","first-page":"303","article-title":"The role of Pseudomonas species in patients treated with ampicillin and sulbactam for gangrenous and perforated appendicitis","volume":"161","author":"Yellin A. E.","year":"1985","unstructured":"YellinA. E. HeseltineP. N. BerneT. V.. 1985. The role of Pseudomonas species in patients treated with ampicillin and sulbactam for gangrenous and perforated appendicitis. Surg. Gynecol. Obstet. 161:303\u2013307.","journal-title":"Surg. Gynecol. Obstet"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.4.1151-1161.2001"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00070-11","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00070-11","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T23:16:55Z","timestamp":1645485415000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.00070-11"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8]]},"references-count":39,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2011,8]]}},"alternative-id":["10.1128\/AAC.00070-11"],"URL":"https:\/\/doi.org\/10.1128\/aac.00070-11","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,8]]},"assertion":[{"value":"2011-01-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-06-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-07-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}