{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T11:06:57Z","timestamp":1778756817286,"version":"3.51.4"},"reference-count":25,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"Fund of the Bureau of Science and Technology of Henan Province","award":["142300410079"],"award-info":[{"award-number":["142300410079"]}]},{"name":"Fund of the Bureau of Science and Technology of Henan Province","award":["132102310425"],"award-info":[{"award-number":["132102310425"]}]},{"name":"Fund of the Bureau of Health of Henan Province","award":["201002012"],"award-info":[{"award-number":["201002012"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81241033"],"award-info":[{"award-number":["81241033"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The interaction of natamycin-azithromycin combination against 60 ocular fungal isolates was tested\n            <jats:italic>in vitro<\/jats:italic>\n            . The combination produced 100% synergistic interactions when natamycin was added to azithromycin 20, 40, and 50 \u03bcg\/ml against\n            <jats:named-content content-type=\"genus-species\">Aspergillus flavus<\/jats:named-content>\n            species complex (AFSC) isolates and to azithromycin 50 \u03bcg\/ml against\n            <jats:named-content content-type=\"genus-species\">Fusarium solani<\/jats:named-content>\n            species complex isolates. Addition of 50 \u03bcg\/ml azithromycin enhanced natamycin's effect against AFSC isolates by reducing natamycin MIC\n            <jats:sub>90<\/jats:sub>\n            from 64 to 0.031 \u03bcg\/ml. No antagonism was observed.\n          <\/jats:p>","DOI":"10.1128\/aac.00077-18","type":"journal-article","created":{"date-parts":[[2018,5,4]],"date-time":"2018-05-04T08:35:22Z","timestamp":1525422922000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":5,"title":["Natamycin and Azithromycin Are Synergistic\n            <i>In Vitro<\/i>\n            against Ocular Pathogenic Aspergillus flavus Species Complex and Fusarium solani Species Complex Isolates"],"prefix":"10.1128","volume":"62","author":[{"given":"Haoyi","family":"Guo","sequence":"first","affiliation":[{"name":"Henan Eye Hospital &amp; Henan Eye Institute, Department of Ophthalmology, Henan Provincial People's Hospital, Zhengzhou, Henan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lutan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Optometry, Zhengzhou Railway Vocational &amp; Technical College, Zhengzhou, Henan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"He","sequence":"additional","affiliation":[{"name":"Henan Eye Hospital &amp; Henan Eye Institute, Department of Ophthalmology, Henan Provincial People's Hospital, Zhengzhou, Henan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuanwen","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Zhengzhou Second Hospital, Zhengzhou, Henan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Han","sequence":"additional","affiliation":[{"name":"Henan Eye Hospital &amp; Henan Eye Institute, Department of Ophthalmology, Henan Provincial People's Hospital, Zhengzhou, Henan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Xu","sequence":"additional","affiliation":[{"name":"Henan Eye Hospital &amp; Henan Eye Institute, Department of Ophthalmology, Henan Provincial People's Hospital, Zhengzhou, Henan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1089\/jop.2012.0155"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00714-09"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2008.04.019"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e318277ac74"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2013.10.004"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e31823f8ae0"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.4103\/0301-4738.83614"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.4103\/0301-4738.86328"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.16.4.730-797.2003"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e318199fa77"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00697-08"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.125.6.789"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2012.02194.x"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2005.10.063"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00610-08"},{"key":"e_1_3_2_17_2","volume-title":"Medical mycology\u2014guide to laboratory examination","author":"Wang DL","year":"2005","unstructured":"Wang DL (ed). 2005. 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