{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T19:48:30Z","timestamp":1791143310995,"version":"4.1.0"},"reference-count":38,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Topical mupirocin is used widely to treat skin and soft tissue infections and to eradicate nasal carriage of methicillin-resistant\n                    <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Staphylococcus aureus<\/jats:named-content>\n                    (MRSA). Few studies to date have characterized the rates of\n                    <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">S. aureus<\/jats:named-content>\n                    mupirocin resistance in pediatric populations. We retrospectively studied 358 unique\n                    <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">S. aureus<\/jats:named-content>\n                    isolates obtained from 249 children seen in a predominantly outpatient setting by the Division of Pediatric Dermatology at a major academic center in New York City between 1 May 2012 and 17 September 2013. Mupirocin resistance rates and the associated risk factors were determined using a logistic regression analysis. In our patient population, 19.3% of patients had mupirocin-resistant\n                    <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">S. aureus<\/jats:named-content>\n                    isolates at the time of their first culture, and 22.1% of patients with\n                    <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">S. aureus<\/jats:named-content>\n                    infection had a mupirocin-resistant isolate at some time during the study period. Overall, 31.3% of all\n                    <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">S. aureus<\/jats:named-content>\n                    isolates collected during the study period were resistant to mupirocin. Prior mupirocin use was strongly correlated (odds ratio [OR] = 26.5;\n                    <jats:italic>P<\/jats:italic>\n                    = &lt;0.001) with mupirocin resistance. Additional risk factors for mupirocin resistance included methicillin resistance, atopic dermatitis (AD), epidermolysis bullosa (EB), immunosuppression, and residence in northern Manhattan and the Bronx. Resistance to mupirocin is widespread in children with dermatologic complaints in the New York City area, and given the strong association with mupirocin exposure, it is likely that mupirocin use contributes to the increased resistance. Routine mupirocin testing may be important for MRSA decolonization strategies or the treatment of minor skin infections in children.\n                  <\/jats:p>","DOI":"10.1128\/aac.00079-15","type":"journal-article","created":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T05:41:41Z","timestamp":1427866901000},"page":"3350-3356","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":91,"title":["High Prevalence of Mupirocin Resistance in Staphylococcus aureus Isolates from a Pediatric Population"],"prefix":"10.1128","volume":"59","author":[{"given":"Nina K.","family":"Antonov","sequence":"first","affiliation":[{"name":"College of Physicians and Surgeons, Columbia University, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria C.","family":"Garzon","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Columbia University Medical Center, New York, New York, USA"},{"name":"Department of Pediatrics, Columbia University Medical Center, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly D.","family":"Morel","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Columbia University Medical Center, New York, New York, USA"},{"name":"Department of Pediatrics, Columbia University Medical Center, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Whittier","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Columbia University Medical Center, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Planet","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Columbia University Medical Center, New York, New York, USA"},{"name":"Sackler Institute for Comparative Genomics, American Museum of Natural History, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine T.","family":"Lauren","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Columbia University Medical Center, New York, New York, USA"},{"name":"Department of Pediatrics, Columbia University Medical Center, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2006.01.001"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)92398-1"},{"key":"e_1_3_3_4_2","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1016\/S0140-6736(87)91179-2","article-title":"Mupirocin-resistant Staphylococcus aureus","author":"Kavi J","year":"1987","unstructured":"Kavi J, Andrews JM, Wise R, Smith MD, Sanghrajka M, Lock S. 1987. 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