{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T05:17:33Z","timestamp":1787980653860,"version":"build-2784847793"},"reference-count":51,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R15AI105742"],"award-info":[{"award-number":["R15AI105742"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:p>Urinary biomarkers are superior to serum creatinine for defining onset and extent of kidney injury. This study classifies the temporal predictive ability of biomarkers for vancomycin-induced kidney injury (VIKI) as defined by histopathologic damage.<\/jats:p>","DOI":"10.1128\/aac.00079-19","type":"journal-article","created":{"date-parts":[[2019,4,16]],"date-time":"2019-04-16T06:51:02Z","timestamp":1555397462000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":55,"title":["Comparative Performance of Urinary Biomarkers for Vancomycin-Induced Kidney Injury According to Timeline of Injury"],"prefix":"10.1128","volume":"63","author":[{"given":"Gwendolyn M.","family":"Pais","sequence":"first","affiliation":[{"name":"Department of Pharmacy Practice, Chicago College of Pharmacy, Midwestern University, Downers Grove, Illinois, USA"},{"name":"Pharmacometrics Center of Excellence, Chicago College of Pharmacy, Midwestern University, Downers Grove, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean N.","family":"Avedissian","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, Chicago College of Pharmacy, Midwestern University, Downers Grove, Illinois, USA"},{"name":"Pharmacometrics Center of Excellence, Chicago College of Pharmacy, Midwestern University, Downers Grove, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5184-1385","authenticated-orcid":false,"given":"J. Nicholas","family":"O\u2019Donnell","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, Albany College of Pharmacy and Health Sciences, Albany, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0018-5434","authenticated-orcid":false,"given":"Nathaniel J.","family":"Rhodes","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, Chicago College of Pharmacy, Midwestern University, Downers Grove, Illinois, USA"},{"name":"Pharmacometrics Center of Excellence, Chicago College of Pharmacy, Midwestern University, Downers Grove, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas P.","family":"Lodise","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, Albany College of Pharmacy and Health Sciences, Albany, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter C.","family":"Prozialeck","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, College of Graduate Studies, Midwestern University, Downers Grove, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter C.","family":"Lamar","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, College of Graduate Studies, Midwestern University, Downers Grove, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cameron","family":"Cluff","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, Chicago College of Pharmacy, Midwestern University, Downers Grove, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil","family":"Gulati","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Chicago College of Pharmacy, Midwestern University, Downers Grove, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie C.","family":"Fitzgerald","sequence":"additional","affiliation":[{"name":"Division of Critical Care, Department of Anesthesiology and Critical Care, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin J.","family":"Downes","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA"},{"name":"Department of Pediatrics, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athena F.","family":"Zuppa","sequence":"additional","affiliation":[{"name":"Division of Critical Care, Department of Anesthesiology and Critical Care, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1091-6130","authenticated-orcid":false,"given":"Marc H.","family":"Scheetz","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, Chicago College of Pharmacy, Midwestern University, Downers Grove, Illinois, USA"},{"name":"Pharmacometrics Center of Excellence, Chicago College of Pharmacy, Midwestern University, Downers Grove, Illinois, USA"},{"name":"Department of Pharmacology, College of Graduate Studies, Midwestern University, Downers Grove, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.168.20.2254"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir672"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2015.226"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2016.5651"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit614"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-012-1259-9"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00173-11"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1086\/600884"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1086\/600877"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2011.12.013"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp080434"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir895"},{"key":"e_1_3_3_14_2","volume-title":"HCUP Statistical Brief #180. Overview of hospital stays in the Unites States, 2012","author":"Weiss AJ","year":"2014","unstructured":"Weiss AJ, Elixhauser A. 2014. HCUP Statistical Brief #180. Overview of hospital stays in the Unites States, 2012. Agency for Healthcare Reserach and Quality, Rockville, MD. https:\/\/www.hcup-us.ahrq.gov\/reports\/statbriefs\/sb180-Hospitalizations-United-States-2012.pdf."},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00416-17"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00591-16"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-008-1060-2"},{"key":"e_1_3_3_18_2","volume-title":"Biomarker qualification determination letter","author":"Critical Path Institute Predictive Safety Testing Consortium","year":"2018","unstructured":"Critical Path Institute Predictive Safety Testing Consortium. 2018. Biomarker qualification determination letter. Critical Path Institute, London, UK. https:\/\/c-path.org\/programs\/pstc\/."},{"key":"e_1_3_3_19_2","volume-title":"Letter of support for drug-induced vascular injury (DIVI) biomarker(s)","author":"U.S. Food and Drug Administration","year":"2016","unstructured":"U.S. Food and Drug Administration. 2016. Letter of support for drug-induced vascular injury (DIVI) biomarker(s). U.S. Food and Drug Administration, Washington, DC. https:\/\/www.fda.gov\/downloads\/Drugs\/DevelopmentApprovalProcess\/UCM530365.pdf."},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2017.08.012"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1177\/0192623312444618"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt0510-436"},{"key":"e_1_3_3_23_2","first-page":"482","article-title":"Vancomycin-induced nephrotoxicity in rats: is enzyme elevation a consistent finding in tubular injury?","volume":"20","author":"Naghibi B","year":"2007","unstructured":"Naghibi B, Ghafghazi T, Hajhashemi V, Talebi A. 2007. Vancomycin-induced nephrotoxicity in rats: is enzyme elevation a consistent finding in tubular injury? J Nephrol 20:482\u2013488.","journal-title":"J Nephrol"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfn203"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1177\/2042018816638223"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1080\/1071576031000061002"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2005.07.009"},{"key":"e_1_3_3_28_2","first-page":"1","article-title":"KDIGO clinical practice guideline for acute kidney injury","volume":"2","author":"Kidney Disease: Improving Global Outcomes (KDIGO) Acute Kidney Injury Work Group","year":"2012","unstructured":"Kidney Disease: Improving Global Outcomes (KDIGO) Acute Kidney Injury Work Group. 2012. KDIGO clinical practice guideline for acute kidney injury. Kidney Int Suppl 2:1\u2013138.","journal-title":"Kidney Int Suppl"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc2872"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-2712(18)30459-1"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2008070669"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2004.03.013"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2002.00433.x"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2018.09.011"},{"key":"e_1_3_3_35_2","first-page":"4203","article-title":"Urinary kidney injury molecule-1 and neutrophil gelatinase-associated lipocalin as early biomarkers for predicting vancomycin-associated acute kidney injury: a prospective study","volume":"21","author":"Pang HM","year":"2017","unstructured":"Pang HM, Qin XL, Liu TT, Wei WX, Cheng DH, Lu H, Guo Q, Jing L. 2017. Urinary kidney injury molecule-1 and neutrophil gelatinase-associated lipocalin as early biomarkers for predicting vancomycin-associated acute kidney injury: a prospective study. Eur Rev Med Pharmacol Sci 21:4203\u20134213.","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc11855"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1080\/08035250510031610"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2010.23"},{"key":"e_1_3_3_39_2","volume-title":"Guide for the care and use of laboratory animals","author":"National Research Council","year":"2011","unstructured":"National Research Council. 2011. Guide for the care and use of laboratory animals, 8th ed. National Academies Press, Washington, DC.","edition":"8"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1623"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01602-07"},{"key":"e_1_3_3_42_2","volume-title":"Estimating the maximum safe starting dose in initial clinical trials for therapeutics in adult healthy volunteers","author":"U.S. Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research (CDER)","year":"2005","unstructured":"U.S. Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research (CDER). 2005. Guidance for industry. Estimating the maximum safe starting dose in initial clinical trials for therapeutics in adult healthy volunteers. Center for Drug Evaluation and Research (CDER), Washington, DC."},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2009.01.016"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2009.01.012"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2008.270"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1622"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1627"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1624"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1634"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002467"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01564-15"},{"key":"e_1_3_3_52_2","unstructured":"OpenStax College. 19 June 2013. Blood flow in the nephron. Illustration from anatomy & physiology Connexions Web site. https:\/\/commons.wikimedia.org\/wiki\/File:2611_Blood_Flow_in_the_Nephron.jpg. Accessed 20 February 2018."}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00079-19","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00079-19","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T16:39:16Z","timestamp":1645461556000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.00079-19"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":51,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["10.1128\/AAC.00079-19"],"URL":"https:\/\/doi.org\/10.1128\/aac.00079-19","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"2019-01-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00079-19"}}