{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T17:30:55Z","timestamp":1762623055194},"reference-count":9,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T00:00:00Z","timestamp":1185926400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            We developed a guinea pig model of cryptococcal meningitis to evaluate antifungal agents. Immunosuppressed animals challenged intracranially with\n            <jats:italic>Cryptococcus neoformans<\/jats:italic>\n            responded to fluconazole and voriconazole. Disease was monitored by serial cerebrospinal fluid (CSF) cultures and quantitative organ cultures. Our model produces disseminating central nervous system disease and responds to antifungal therapy.\n          <\/jats:p>","DOI":"10.1128\/aac.00085-07","type":"journal-article","created":{"date-parts":[[2007,6,12]],"date-time":"2007-06-12T02:32:47Z","timestamp":1181615567000},"page":"3011-3013","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":22,"title":["New Guinea Pig Model of Cryptococcal Meningitis"],"prefix":"10.1128","volume":"51","author":[{"given":"William R.","family":"Kirkpatrick","sequence":"first","affiliation":[{"name":"Department of Medicine, The University of Texas Health Science Center at San Antonio, Texas 78229-3900"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura K.","family":"Najvar","sequence":"additional","affiliation":[{"name":"Department of Medicine, The University of Texas Health Science Center at San Antonio, Texas 78229-3900"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosie","family":"Bocanegra","sequence":"additional","affiliation":[{"name":"Department of Medicine, The University of Texas Health Science Center at San Antonio, Texas 78229-3900"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas F.","family":"Patterson","sequence":"additional","affiliation":[{"name":"Department of Medicine, The University of Texas Health Science Center at San Antonio, Texas 78229-3900"},{"name":"Audie Murphy Division, South Texas Veterans Health Care System, San Antonio, Texas 78284"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John R.","family":"Graybill","sequence":"additional","affiliation":[{"name":"Department of Medicine, The University of Texas Health Science Center at San Antonio, Texas 78229-3900"},{"name":"Audie Murphy Division, South Texas Veterans Health Care System, San Antonio, Texas 78284"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","first-page":"292","volume":"129","year":"1984","unstructured":"Graybill, J. 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