{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T09:15:09Z","timestamp":1791191709405,"version":"4.1.0"},"reference-count":21,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            We compared the activity of dicloxacillin with that of vancomycin against 15 oxacillin-susceptible, methicillin-resistant\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Staphylococcus aureus<\/jats:named-content>\n            (OS-MRSA) clinical isolates. By population analyses, we found that 6 OS-MRSA isolates were able to grow in the presence of up to 8 \u03bcg\/ml dicloxacillin and 9 isolates were able to grow in 12 to &gt;32 \u03bcg\/ml dicloxacillin; all isolates grew in up to 2 \u03bcg\/ml vancomycin. Both drugs exhibited similar bactericidal activities. In experimental infections, the therapeutic efficacy of dicloxacillin was significant (\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.05 versus untreated controls) in 10 OS-MRSA isolates and vancomycin was effective (\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.05) against 12 isolates; dicloxacillin had an efficacy that was comparable to that of vancomycin (\n            <jats:italic>P<\/jats:italic>\n            &gt; 0.05) in 8 isolates. The favorable response to dicloxacillin treatment might suggest that antistaphylococcal penicillins could be used against OS-MRSA infections.\n          <\/jats:p>","DOI":"10.1128\/aac.00103-12","type":"journal-article","created":{"date-parts":[[2012,3,20]],"date-time":"2012-03-20T03:32:13Z","timestamp":1332214333000},"page":"3388-3391","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":24,"title":["Activity of Oxacillin versus That of Vancomycin against Oxacillin-Susceptible\n            <i>mecA<\/i>\n            -Positive Staphylococcus aureus Clinical Isolates Evaluated by Population Analyses, Time-Kill Assays, and a Murine Thigh Infection Model"],"prefix":"10.1128","volume":"56","author":[{"given":"Maria","family":"Labrou","sequence":"first","affiliation":[{"name":"Department of Microbiology, Medical School, University of Thessaly, Larissa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Michail","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Medical School, University of Thessaly, Larissa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni","family":"Ntokou","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Medical School, University of Thessaly, Larissa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodore E.","family":"Pittaras","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Medical School, University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spyros","family":"Pournaras","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Medical School, University of Thessaly, Larissa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athanassios","family":"Tsakris","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Medical School, University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.11.3484-3489.2002"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2009.07.024"},{"key":"e_1_3_2_4_2","volume-title":"Abstr. 48th Annu. Intersci. Conference Antimicrob. Agents Chemother. (ICAAC)","author":"Chini S","year":"2008","unstructured":"ChiniS. 2008. Clonal evolution and antibiotic resistance profile of methicillin-resistant Staphylococcus aureus in Greece during a five-year period, abstr C2-231, p 156. Abstr. 48th Annu. Intersci. Conference Antimicrob. Agents Chemother. (ICAAC). American Society for Microbiology, Washington, DC."},{"key":"e_1_3_2_5_2","volume-title":"Approved standard M07-A8","author":"Clinical and Laboratory Standards Institute","year":"2009","unstructured":"Clinical and Laboratory Standards Institute. 2009. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically, 8th ed. Approved standard M07-A8. Clinical and Laboratory Standards Institute, Wayne, PA."},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.38.3.1008-1015.2000"},{"key":"e_1_3_2_7_2","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1093\/jac\/dkq039","article-title":"Detection of mutations in the FemXAB protein family in oxacillin-susceptible mecA-positive Staphylococcus aureus clinical isolates","volume":"65","author":"Giannouli S","year":"2010","unstructured":"GiannouliS. 2010. Detection of mutations in the FemXAB protein family in oxacillin-susceptible mecA-positive Staphylococcus aureus clinical isolates. J. Antimicrob. Chemother. 65:626\u2013633.","journal-title":"J. Antimicrob. 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Oxacillin-susceptible MRSA, the emerging MRSA clone in the UK? J. Hosp. Infect. 76:267\u2013268.","journal-title":"J. Hosp. Infect."},{"key":"e_1_3_2_19_2","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1186\/ar406","article-title":"Combined antibiotic and free radical trap treatment is effective at combating Staphylococcus aureus-induced septic arthritis","volume":"4","author":"Sakiniene E","year":"2002","unstructured":"SakinieneE CollinsLV. 2002. Combined antibiotic and free radical trap treatment is effective at combating Staphylococcus aureus-induced septic arthritis. Arthritis Res. 4:196\u2013200.","journal-title":"Arthritis Res."},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.39.11.3946-3951.2001"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.34.6.1227"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.36.6.1653-1659.1998"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00103-12","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00103-12","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T22:12:40Z","timestamp":1645481560000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.00103-12"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6]]},"references-count":21,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["10.1128\/AAC.00103-12"],"URL":"https:\/\/doi.org\/10.1128\/aac.00103-12","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6]]},"assertion":[{"value":"2012-01-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-03-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-05-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}