{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T02:35:28Z","timestamp":1773282928113,"version":"3.50.1"},"reference-count":36,"publisher":"American Society for Microbiology","issue":"10","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The emergence of\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Neisseria gonorrhoeae<\/jats:named-content>\n            isolates displaying resistance to antimicrobial agents is a major public health concern and a serious issue related to the occurrence of further untreatable gonorrhea infections. A retrospective analysis on 1,430\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">N. gonorrhoeae<\/jats:named-content>\n            isolates, collected from 2003 through 2012, for antimicrobial susceptibility by Etest and molecular characterization by\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Neisseria gonorrhoeae<\/jats:named-content>\n            multiantigen sequence typing (NG-MAST) was carried out in Italy. Azithromycin-resistant gonococci decreased from 14% in 2007 to 2.2% in 2012. Similarly, isolates with high MICs to cefixime (&gt;0.125 mg\/liter) decreased from 11% in 2008 to 3.3% in 2012. The ciprofloxacin resistance rate remains quite stable, following an increasing trend up to 64% in 2012. The percentage of penicillinase-producing\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">N. gonorrhoeae<\/jats:named-content>\n            (PPNG) significantly declined from 77% in 2003 to 7% in 2012. A total of 81 multidrug-resistant (MDR) gonococci were identified, showing 11 different antimicrobial resistance patterns. These were isolated from men who have sex with men (MSM) and from heterosexual patients. Two sequence types (STs), ST661 and ST1407, were the most common. Genogroup 1407, which included cefixime-, ciprofloxacin-, and azithromycin-resistant isolates, was found. In conclusion, a change in the antimicrobial resistance profiles among gonococci was identified in Italy together with a percentage of MDR isolates.\n          <\/jats:p>","DOI":"10.1128\/aac.00103-14","type":"journal-article","created":{"date-parts":[[2014,7,29]],"date-time":"2014-07-29T06:34:28Z","timestamp":1406615668000},"page":"5871-5876","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":17,"title":["Changing Antimicrobial Resistance Profiles among Neisseria gonorrhoeae Isolates in Italy, 2003 to 2012"],"prefix":"10.1128","volume":"58","author":[{"given":"Anna","family":"Carannante","sequence":"first","affiliation":[{"name":"Department of Infectious, Parasitic and Immune-mediated Diseases, Istituto Superiore di Sanit\u00e0, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna","family":"Renna","sequence":"additional","affiliation":[{"name":"Department of Infectious, Parasitic and Immune-mediated Diseases, Istituto Superiore di Sanit\u00e0, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivano","family":"Dal Conte","sequence":"additional","affiliation":[{"name":"STI Clinic, Department of Infectious Diseases, Amedeo di Savoia Hospital, Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeria","family":"Ghisetti","sequence":"additional","affiliation":[{"name":"Microbiology and Virology Laboratory, Department of Infectious Diseases, Amedeo di Savoia Hospital, Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Matteelli","sequence":"additional","affiliation":[{"name":"Institute of Infectious and Tropical Diseases, University of Brescia, Brescia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grazia","family":"Prignano","sequence":"additional","affiliation":[{"name":"San Gallicano Dermatologic Institute, IRCSS, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giampaolo","family":"Impara","sequence":"additional","affiliation":[{"name":"San Gallicano Dermatologic Institute, IRCSS, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Cusini","sequence":"additional","affiliation":[{"name":"Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonietta","family":"D'Antuono","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliero-Universitaria di Bologna Policlinico S. Orsola-Malpighi Unit of Dermatology, STDs Center, Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caterina","family":"Vocale","sequence":"additional","affiliation":[{"name":"Unit of Clinical Microbiology, CRREM Laboratory, St. Orsola-Malpighi, University Hospital, Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaele","family":"Antonetti","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, Azienda Ospedaliero-Universitaria OORR, Foggia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Gaino","sequence":"additional","affiliation":[{"name":"Microbiology and Virology Laboratory, Santa Chiara Hospital, Trento, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Busetti","sequence":"additional","affiliation":[{"name":"Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Agnese","family":"Latino","sequence":"additional","affiliation":[{"name":"Laboratorio di Batteriologia, Ospedale Ostetrico Ginecologico Sant'Anna, Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonella","family":"Mencacci","sequence":"additional","affiliation":[{"name":"Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Bonanno","sequence":"additional","affiliation":[{"name":"Microbiology and Virology Laboratory, Sandro Pertini Hospital, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Carmela","family":"Cava","sequence":"additional","affiliation":[{"name":"Microbiology and Virology Laboratory, Sandro Pertini Hospital, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Giraldi","sequence":"additional","affiliation":[{"name":"Microbiology and Virology Laboratory, Molecular Clinic, PO Annunziata Azienda Ospedaliera di Cosenza, Cosenza, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Stefanelli","sequence":"additional","affiliation":[{"name":"Department of Infectious, Parasitic and Immune-mediated Diseases, Istituto Superiore di Sanit\u00e0, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01041-06"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.2147\/IJWH.S13427"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000000058"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000000025"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00325-11"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01295-13"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.05760-11"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dks162"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.2217\/fmb.12.117"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1586\/14787210.2014.906902"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1586\/eri.09.63"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/0956462412472837"},{"key":"e_1_3_2_14_2","first-page":"590","article-title":"Update to CDC's sexually transmitted diseases treatment guidelines, 2010: oral cephalosporins no longer a recommended treatment for gonococcal infection","volume":"61","author":"Centers for Disease Control and Prevention","year":"2012","unstructured":"Centers for Disease Control and Prevention. 2012. Update to CDC's sexually transmitted diseases treatment guidelines, 2010: oral cephalosporins no longer a recommended treatment for gonococcal infection. MMWR Morb. Mortal Wkly. Rep. 61:590\u2013594.","journal-title":"MMWR Morb. Mortal Wkly. Rep."},{"issue":"24","key":"e_1_3_2_15_2","first-page":"pii=20196","article-title":"ECDC public health response to the threat of resistant gonorrhea in Europe","volume":"17","author":"Van de Laar M","year":"2012","unstructured":"Van de LaarM. 2012. ECDC public health response to the threat of resistant gonorrhea in Europe. Euro. Surveill. 17(24):pii=20196. http:\/\/www.eurosurveillance.org\/ViewArticle.aspx?ArticleId=20196.","journal-title":"Euro. Surveill."},{"key":"e_1_3_2_16_2","volume-title":"Gonococcal antimicrobial susceptibility surveillance in Europe 2011","author":"European Centre for Disease Prevention and Control","year":"2013","unstructured":"European Centre for Disease Prevention and Control. 2013. Gonococcal antimicrobial susceptibility surveillance in Europe 2011. European Centre for Disease Prevention and Control. Stockholm, Sweden. http:\/\/www.ecdc.europa.eu\/en\/publications\/publications\/gonococcal-antimicrobial-susceptibility-surveillance-27-mar-2013.pdf."},{"key":"e_1_3_2_17_2","volume-title":"Sexually transmitted infections in Europe 2011","author":"European Centre for Disease Prevention and Control","year":"2013","unstructured":"European Centre for Disease Prevention and Control. 2013. Sexually transmitted infections in Europe 2011. European Centre for Disease Prevention and Control, Stockholm, Sweden. http:\/\/www.ecdc.europa.eu\/en\/publications\/publications\/sexually-transmitted-infections-europe-2011.pdf."},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans-2013-051117"},{"issue":"42","key":"e_1_3_2_19_2","first-page":"pii=19995","article-title":"The European Gonococcal Antimicrobial Surveillance Programme, 2009","volume":"14","author":"Cole MJ","year":"2011","unstructured":"ColeMJUnemoMHoffmannSChisholmSAIsonCAvan der LaarMJ. 2011. The European Gonococcal Antimicrobial Surveillance Programme, 2009. Euro Surveill. 14(42):pii=19995. http:\/\/www.eurosurveillance.org\/ViewArticle.aspx?ArticleId=19995.","journal-title":"Euro Surveill."},{"key":"e_1_3_2_20_2","volume-title":"Breakpoints tables for interpretation of MICs and zone diameters, version 4.0","author":"European Committee on Antimicrobial Susceptibility Testing","year":"2014","unstructured":"European Committee on Antimicrobial Susceptibility Testing. 2014. Breakpoints tables for interpretation of MICs and zone diameters, version 4.0. European Committee on Antimicrobial Susceptibility Testing, V\u00e4xj\u00f6, Sweden. http:\/\/www.eucast.org\/fileadmin\/src\/media\/PDFs\/EUCAST_files\/Breakpoint_tables\/Breakpoint_table_v_4.0.pdf."},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkp098"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1086\/383047"},{"issue":"3","key":"e_1_3_2_23_2","doi-asserted-by":"crossref","first-page":"pii=20358","DOI":"10.2807\/ese.18.03.20358-en","article-title":"Molecular epidemiological typing within the European Gonococcal Antimicrobial Resistance Surveillance Programme reveals predominance of a multidrug-resistant clone","volume":"18","author":"Chisholm SA","year":"2013","unstructured":"ChisholmSAUnemoMQuayeNJohanssonEColeMJIsonCAVan de LaarMJW. 2013. Molecular epidemiological typing within the European Gonococcal Antimicrobial Resistance Surveillance Programme reveals predominance of a multidrug-resistant clone. Euro Surveill. 18(3):pii=20358. http:\/\/www.eurosurveillance.org\/ViewArticle.aspx?ArticleId=20358.","journal-title":"Euro Surveill."},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dku026"},{"key":"e_1_3_2_25_2","volume-title":"Results from a pilot study 2010-2011","author":"European Centre for Disease Prevention and Control","year":"2012","unstructured":"European Centre for Disease Prevention and Control. 2012. Molecular typing of Neisseria gonorrhoeae. Results from a pilot study 2010-2011. European Centre for Disease Prevention and Control, Stockholm, Sweden. http:\/\/www.ecdc.europa.eu\/en\/publications\/Publications\/201211109-Molecular-typing-gonorrhea.pdf."},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.2008.01244.x"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2008.02071.x"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans-2012-050909"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans-2012-050906"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans-2012-050907"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1136\/sti.2010.044164"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2042.2011.02891.x"},{"key":"e_1_3_2_33_2","volume-title":"Global action plan to control the spread and impact of anti-microbial resistance in Neisseria gonorrhoeae","author":"World Health Organization","year":"2012","unstructured":"World Health Organization. 2012. Global action plan to control the spread and impact of anti-microbial resistance in Neisseria gonorrhoeae. World Health Organization, Geneva, Switzerland. http:\/\/whqlibdoc.who.int\/publications\/2012\/9789241503501_eng.pdf."},{"issue":"47","key":"e_1_3_2_34_2","doi-asserted-by":"crossref","first-page":"pii=19721","DOI":"10.2807\/ese.15.47.19721-en","article-title":"Two cases of verified clinical failures using internationally recommended first-line cefixime for gonorrhoea treatment, Norway","volume":"15","author":"Unemo M","year":"2010","unstructured":"UnemoMGolparianDSyversenGVestrheimDFMoiH. 2010. Two cases of verified clinical failures using internationally recommended first-line cefixime for gonorrhoea treatment, Norway. Euro Surveill. 15(47):pii=19721. http:\/\/www.eurosurveillance.org\/ViewArticle.aspx?ArticleId=19721.","journal-title":"Euro Surveill."},{"issue":"43","key":"e_1_3_2_35_2","doi-asserted-by":"crossref","first-page":"pii=19998","DOI":"10.2807\/ese.16.43.19998-en","article-title":"First Neisseria gonorrhoeae strain with resistance to cefixime causing gonorrhoea treatment failure in Austria, 2011","volume":"16","author":"Unemo M","year":"2011","unstructured":"UnemoMGolparianDStaryAEigentlerA. 2011. First Neisseria gonorrhoeae strain with resistance to cefixime causing gonorrhoea treatment failure in Austria, 2011. Euro Surveill. 16(43):pii=19998. http:\/\/www.eurosurveillance.org\/ViewArticle.aspx?ArticleId=19998.","journal-title":"Euro Surveill."},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2011.03619.x"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2011.08.014"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00103-14","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00103-14","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T22:46:00Z","timestamp":1645483560000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.00103-14"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":36,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["10.1128\/AAC.00103-14"],"URL":"https:\/\/doi.org\/10.1128\/aac.00103-14","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10]]},"assertion":[{"value":"2014-01-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-07-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-09-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}