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Praziquantel, the sole drug currently approved for schistosomiasis treatment, demonstrates effectiveness against patent infections. A recent study highlighted the antiparasitic properties of amiodarone, an anti-arrhythmic drug, exhibiting higher efficacy than praziquantel against prepatent infections. This study assessed the efficacy of amiodarone and praziquantel, both individually and in combination, against\n              <jats:italic>Schistosoma mansoni<\/jats:italic>\n              through comprehensive\n              <jats:italic>in vitro<\/jats:italic>\n              and\n              <jats:italic>in vivo<\/jats:italic>\n              experiments.\n              <jats:italic>In vitro<\/jats:italic>\n              experiments demonstrated synergistic activity (fractional inhibitory concentration index \u22640.5) for combinations of amiodarone with praziquantel. In a murine model of schistosomiasis featuring prepatent infections, treatments involving amiodarone (200 or 400 mg\/kg) followed by praziquantel (200 or 400 mg\/kg) yielded a substantial reduction in worm burden (60%\u201370%). Given the low efficacy of praziquantel in prepatent infections, combinations of amiodarone with praziquantel may offer clinical utility in the treatment of schistosomiasis.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1128\/aac.00114-24","type":"journal-article","created":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T13:00:38Z","timestamp":1716469238000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":2,"title":["<i>In vitro<\/i>\n            and\n            <i>in vivo<\/i>\n            efficacy of the amiodarone and praziquantel combination against the blood fluke\n            <i>Schistosoma mansoni<\/i>"],"prefix":"10.1128","volume":"68","author":[{"given":"Rayssa A.","family":"Cajas","sequence":"first","affiliation":[{"name":"Research Center on Neglected Diseases, Guarulhos University, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia S. B.","family":"Santos","sequence":"additional","affiliation":[{"name":"Research Center on Neglected Diseases, Guarulhos University, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Cristina C.","family":"Esp\u00edrito-Santo","sequence":"additional","affiliation":[{"name":"Department of Infectious and Parasitic Diseases, Faculty of Medicine, Laboratory of Immunopathology of Schistosomiasis (LIM-06), University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"},{"name":"Laboratory of Helminthology, Institute of Tropical Medicine, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2976-2706","authenticated-orcid":false,"given":"Yagoob","family":"Garedaghi","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Faculty of Veterinary Medicine, Tabriz Medical Sciences, Islamic Azad University, Tabriz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1766-7031","authenticated-orcid":true,"given":"Josu\u00e9","family":"de Moraes","sequence":"additional","affiliation":[{"name":"Research Center on Neglected Diseases, Guarulhos University, S\u00e3o Paulo, Brazil"},{"name":"Research Center on Neglected Diseases, Scientific and Technological Institute, Brazil University, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_4_2_2","unstructured":"World Health Organization. 2024. 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