{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T15:50:34Z","timestamp":1772639434443,"version":"3.50.1"},"reference-count":38,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2007,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            We compared the efficacy of a novel rifamycin derivative, ABI-0043, with that of rifampin, alone and in combination with levofloxacin, against methicillin-susceptible\n            <jats:italic>Staphylococcus aureus<\/jats:italic>\n            ATCC 29213 in a guinea pig tissue-cage infection model. The MIC, logarithmic-growth-phase minimal bactericidal concentration, and stationary-growth-phase minimal bactericidal concentration of ABI-0043 were 0.001, 0.008, and 0.25 \u03bcg\/ml, respectively; the corresponding concentrations of rifampin were 0.016, 0.8, and 3.6 \u03bcg\/ml, respectively. After a single intraperitoneal dose of 12.5 mg\/kg of body weight, the peak concentration in cage fluid was 1.13 \u03bcg\/ml of ABI-0043 and 0.98 \u03bcg\/ml of rifampin. Five days after completion of treatment, levofloxacin administered alone (5 mg\/kg\/12 h) resulted in bacterial counts in cage fluid that were similar to those for untreated controls (&gt;8.0 log\n            <jats:sub>10<\/jats:sub>\n            CFU\/ml), whereas rifampin and ABI-0043 administered alone (12.5 mg\/kg\/12 h) decreased the mean titers of bacteria \u00b1 standard deviations to 1.43 \u00b1 0.28 log\n            <jats:sub>10<\/jats:sub>\n            and 1.57 \u00b1 0.53 log\n            <jats:sub>10<\/jats:sub>\n            CFU\/ml, respectively, in cage fluid. In combination with levofloxacin, both rifamycins cleared bacteria from the cage fluid. The cure rates of cage-associated infections with rifampin and ABI-0043 administered alone were 46% and 58%, respectively, and increased to 88% and 92% in combination with levofloxacin. Emergence of rifamycin resistance was observed in 42% of cages after ABI-0043 therapy and in 38% of cages after rifampin therapy; no emergence of resistance occurred with combination treatment with levofloxacin. In conclusion, ABI-0043 had cure rates comparable to that of rifampin. ABI-0043 in combination with a quinolone has the potential for treatment of implant-associated infections caused by susceptible strains of\n            <jats:italic>S. aureus<\/jats:italic>\n            , potentially without drug-drug interactions.\n          <\/jats:p>","DOI":"10.1128\/aac.00120-07","type":"journal-article","created":{"date-parts":[[2007,5,15]],"date-time":"2007-05-15T00:58:40Z","timestamp":1179190720000},"page":"2540-2545","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":45,"title":["Efficacy of a Novel Rifamycin Derivative, ABI-0043, against\n            <i>Staphylococcus aureus<\/i>\n            in an Experimental Model of Foreign-Body Infection"],"prefix":"10.1128","volume":"51","author":[{"given":"Andrej","family":"Trampuz","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases and Hospital Epidemiology, University Hospital, Basel, Switzerland"},{"name":"Infectious Diseases Research Laboratory, Department of Research, University Hospital, Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher K.","family":"Murphy","sequence":"additional","affiliation":[{"name":"ActivBiotics, Inc., Lexington, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M.","family":"Rothstein","sequence":"additional","affiliation":[{"name":"ActivBiotics, Inc., Lexington, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas F.","family":"Widmer","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Hospital Epidemiology, University Hospital, Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Regine","family":"Landmann","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Hospital Epidemiology, University Hospital, Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Werner","family":"Zimmerli","sequence":"additional","affiliation":[{"name":"Basel University Medical Clinic, Kantonsspital, Liestal, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.4.1251-1256.2003"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.39.5.1134"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/24.5.914"},{"key":"e_1_3_2_5_2","first-page":"1332","year":"2005","unstructured":"Brause, B. 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