{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T18:04:11Z","timestamp":1792260251842,"version":"4.4.0"},"reference-count":26,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2006,6,1]],"date-time":"2006-06-01T00:00:00Z","timestamp":1149120000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Ciprofloxacin-resistant\n            <jats:italic>Escherichia coli<\/jats:italic>\n            isolates (\n            <jats:italic>n<\/jats:italic>\n            = 1,858) from outpatient midstream urine specimens at 40 North American clinical\nlaboratories in 2004 to 2005 were frequently resistant to ampicillin\n(79.8% of isolates) and trimethoprim-sulfamethoxazole (66.5%);\nconcurrent resistance to cefdinir (9.0%) or nitrofurantoin (4.0%) was\nless common. Only 10.8% of isolates were resistant to ciprofloxacin\nalone. Fluoroquinolone-resistant isolates of\n            <jats:italic>E. coli<\/jats:italic>\n            from\nurine were frequently multidrug\nresistant.\n          <\/jats:p>","DOI":"10.1128\/aac.00123-06","type":"journal-article","created":{"date-parts":[[2006,5,24]],"date-time":"2006-05-24T21:13:58Z","timestamp":1148505238000},"page":"2251-2254","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":109,"title":["Fluoroquinolone-Resistant Urinary Isolates of\n            <i>Escherichia coli<\/i>\n            from Outpatients Are Frequently Multidrug Resistant: Results from the NorthAmerican Urinary Tract Infection Collaborative Alliance-QuinoloneResistance Study"],"prefix":"10.1128","volume":"50","author":[{"given":"James A.","family":"Karlowsky","sequence":"first","affiliation":[{"name":"Department\rof Clinical Microbiology, Health Sciences Centre\/Diagnostic Services of\rManitoba"},{"name":"Department of\rMedical 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