{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T13:18:33Z","timestamp":1790687913449,"version":"4.1.0"},"reference-count":18,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[2006,9,1]],"date-time":"2006-09-01T00:00:00Z","timestamp":1157068800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            To test the hypothesis that establishing gastrointestinal colonization with multiresistant\n            <jats:italic>Enterococcus faecium<\/jats:italic>\n            (VRE) C68 results from expansion of the enterococcal population in the upper small bowel, we compared VRE quantities recovered from the proximal, middle, and distal segments of the small bowel from mice treated with different antimicrobial agents. Antibiotics associated with high-level VRE fecal colonization (cefotetan, ceftriaxone, clindamycin, and ticarcillin-clavulanic acid) increased VRE quantities in all small-bowel segments, whereas cefepime and piperacillin-tazobactam did not. Enterococcal expansion did not correlate with reductions in numbers of native gram-negative or anaerobic flora. Green fluorescence protein-expressing\n            <jats:italic>E. faecium<\/jats:italic>\n            bacteria were found adjacent to the small bowel epithelial lining in colonized mice. These data indicate that enterococcal bowel colonization begins within the proximal small bowel and does not correlate with inhibition of other cultivable flora. Host or enterococcal factors induced by exposures to certain antibiotics may play a role in facilitating\n            <jats:italic>E. faecium<\/jats:italic>\n            colonization of the mammalian gastrointestinal tract.\n          <\/jats:p>","DOI":"10.1128\/aac.00125-06","type":"journal-article","created":{"date-parts":[[2006,8,28]],"date-time":"2006-08-28T18:10:56Z","timestamp":1156788656000},"page":"3117-3123","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":21,"title":["Antibiotic-Induced Enterococcal Expansion in the Mouse Intestine Occurs throughout the Small Bowel and Correlates Poorly with Suppression of Competing Flora"],"prefix":"10.1128","volume":"50","author":[{"given":"Viera","family":"Laktic\u0300ova\u0301","sequence":"first","affiliation":[{"name":"Cleveland VA Research and Education Foundation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Hutton-Thomas","sequence":"additional","affiliation":[{"name":"Medical Service and Research Services, Louis Stokes Cleveland VA Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Meyer","sequence":"additional","affiliation":[{"name":"Department of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evren","family":"Gurkan","sequence":"additional","affiliation":[{"name":"Electrical Engineering and Computer Science, Case Western Reserve University, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis B.","family":"Rice","sequence":"additional","affiliation":[{"name":"Medical Service and Research Services, Louis Stokes Cleveland VA Medical Center"},{"name":"Cleveland VA Research and Education Foundation"},{"name":"Department of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.6.2246-2259.2005"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.158.10.1127"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.180.17.4426-4434.1998"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200012283432604"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1086\/315428"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1086\/314874"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.17.5369"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.66.10.4200-4204.2000"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/21.5.1234"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2004.10.001"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0147-619X(03)00020-9"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1086\/428090"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1086\/321807"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.5.1480-1486.2001"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1086\/382086"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1086\/425580"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0147-619X(91)90044-W"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/21.1.45"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00125-06","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00125-06","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T19:14:37Z","timestamp":1645470877000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.00125-06"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9]]},"references-count":18,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2006,9]]}},"alternative-id":["10.1128\/AAC.00125-06"],"URL":"https:\/\/doi.org\/10.1128\/aac.00125-06","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,9]]},"assertion":[{"value":"2006-01-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2006-06-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2006-09-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}