{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T23:23:26Z","timestamp":1791933806174,"version":"4.3.4"},"reference-count":20,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Azole resistance in\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Aspergillus fumigatus<\/jats:named-content>\n            is an emerging public health concern. Recently, a novel fungicide-driven mutation in the\n            <jats:italic>cyp51A<\/jats:italic>\n            gene and its promoter, TR\n            <jats:sub>46<\/jats:sub>\n            \/Y121F\/T289A, leading to high-level resistance to voriconazole has been identified in The Netherlands, Belgium, Germany, Denmark, Tanzania, and India in both clinical and environmental samples. Here we report the first description of\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">A. fumigatus<\/jats:named-content>\n            carrying this mutation in France, in a cystic fibrosis patient, underlining the need for extensive monitoring of\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Aspergillus<\/jats:named-content>\n            resistance.\n          <\/jats:p>","DOI":"10.1128\/aac.00127-15","type":"journal-article","created":{"date-parts":[[2015,4,28]],"date-time":"2015-04-28T01:51:47Z","timestamp":1430185907000},"page":"4331-4335","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":68,"title":["First Description of Azole-Resistant Aspergillus fumigatus Due to TR\n            <sub>46<\/sub>\n            \/Y121F\/T289A Mutation in France"],"prefix":"10.1128","volume":"59","author":[{"given":"Rose-Anne","family":"Lavergne","sequence":"first","affiliation":[{"name":"D\u00e9partement de Parasitologie et Mycologie M\u00e9dicale, Universit\u00e9 de Nantes, Nantes Atlantique Universit\u00e9s, EA1155-IICiMed, Facult\u00e9 de Pharmacie, Nantes, France"},{"name":"Laboratoire de Parasitologie-Mycologie, Institut de Biologie, CHU de Nantes, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florent","family":"Morio","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Parasitologie et Mycologie M\u00e9dicale, Universit\u00e9 de Nantes, Nantes Atlantique Universit\u00e9s, EA1155-IICiMed, Facult\u00e9 de Pharmacie, Nantes, France"},{"name":"Laboratoire de Parasitologie-Mycologie, Institut de Biologie, CHU de Nantes, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lo\u00efc","family":"Favennec","sequence":"additional","affiliation":[{"name":"EA3800, Laboratoire de Parasitologie-Mycologie, Universit\u00e9 de Rouen et CHU de Rouen, Rouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Dominique","sequence":"additional","affiliation":[{"name":"Department of Pneumology, Cystic Fibrosis Center, Rouen University Hospital, Rouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3253-6080","authenticated-orcid":false,"given":"Jacques F.","family":"Meis","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands"},{"name":"Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Gargala","sequence":"additional","affiliation":[{"name":"EA3800, Laboratoire de Parasitologie-Mycologie, Universit\u00e9 de Rouen et CHU de Rouen, Rouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul E.","family":"Verweij","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrice","family":"Le Pape","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Parasitologie et Mycologie M\u00e9dicale, Universit\u00e9 de Nantes, Nantes Atlantique Universit\u00e9s, EA1155-IICiMed, Facult\u00e9 de Pharmacie, Nantes, France"},{"name":"Laboratoire de Parasitologie-Mycologie, Institut de Biologie, CHU de Nantes, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"issue":"48","key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"pii=20326","DOI":"10.2807\/ese.17.48.20326-en","article-title":"Azole-resistant Aspergillus fumigatus due to TR46\/Y121F\/T289A mutation emerging in Belgium, July 2012","volume":"17","author":"Vermeulen E","year":"2012","unstructured":"Vermeulen E, Maertens J, Schoemans H, Lagrou K. 2012. Azole-resistant Aspergillus fumigatus due to TR46\/Y121F\/T289A mutation emerging in Belgium, July 2012. Euro Surveill 17(48):pii=20326. http:\/\/www.eurosurveillance.org\/ViewArticle.aspx?ArticleId=20326.","journal-title":"Euro Surveill"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit320"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dku009"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02855-14"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dku289"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01544-10"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dku566"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkt397"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dku259"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.4.3.625-632.2005"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00156-08"},{"key":"e_1_3_2_13_2","unstructured":"European Committee on Antimicrobial Susceptibility Testing. 2014. Antifungal agents\u2014breakpoint tables for interpretation of MICs version 7.1. http:\/\/www.eucast.org\/fileadmin\/src\/media\/PDFs\/EUCAST_files\/AFST\/Antifungal_breakpoints_v_7.0.pdf."},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dks160"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkq450"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01599-09"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.8.4112-4120.2005"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.00231-09"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.2900\/76274"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000000005"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003633"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00127-15","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00127-15","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T22:58:01Z","timestamp":1645484281000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.00127-15"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":20,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["10.1128\/AAC.00127-15"],"URL":"https:\/\/doi.org\/10.1128\/aac.00127-15","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7]]},"assertion":[{"value":"2015-01-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-04-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-06-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}