{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T19:04:14Z","timestamp":1785179054311,"version":"3.55.0"},"reference-count":32,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            <jats:italic>In vitro<\/jats:italic>\n            activity of the aminoglycoside 6\u2032-\n            <jats:italic>N<\/jats:italic>\n            -acetyltransferase type Ib [AAC(6\u2032)-Ib] was inhibited by ZnCl\n            <jats:sub>2<\/jats:sub>\n            with a 50% inhibitory concentration (IC\n            <jats:sub>50<\/jats:sub>\n            ) of 15 \u03bcM. Growth of\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Acinetobacter baumannii<\/jats:named-content>\n            or\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Escherichia coli<\/jats:named-content>\n            harboring\n            <jats:italic>aac<\/jats:italic>\n            (\n            <jats:italic>6<\/jats:italic>\n            \u2032)-\n            <jats:italic>Ib<\/jats:italic>\n            in cultures containing 8 \u03bcg\/ml amikacin was significantly inhibited by the addition of 2 \u03bcM Zn\n            <jats:sup>2+<\/jats:sup>\n            in complex with the ionophore pyrithione (ZnPT).\n          <\/jats:p>","DOI":"10.1128\/aac.00129-14","type":"journal-article","created":{"date-parts":[[2014,5,13]],"date-time":"2014-05-13T08:07:32Z","timestamp":1399968452000},"page":"4238-4241","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":47,"title":["Inhibition of Aminoglycoside 6\u2032-\n            <i>N<\/i>\n            -Acetyltransferase Type Ib by Zinc: Reversal of Amikacin Resistance in Acinetobacter baumannii and Escherichia coli by a Zinc Ionophore"],"prefix":"10.1128","volume":"58","author":[{"given":"David L.","family":"Lin","sequence":"first","affiliation":[{"name":"Center for Applied Biotechnology Studies, Department of Biological Science, California State University Fullerton, Fullerton, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tung","family":"Tran","sequence":"additional","affiliation":[{"name":"Center for Applied Biotechnology Studies, Department of Biological Science, California State University Fullerton, Fullerton, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamal Y.","family":"Alam","sequence":"additional","affiliation":[{"name":"Center for Applied Biotechnology Studies, Department of Biological Science, California State University Fullerton, Fullerton, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven R.","family":"Herron","sequence":"additional","affiliation":[{"name":"Center for Applied Biotechnology Studies, Department of Biological Science, California State University Fullerton, Fullerton, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Soledad","family":"Ramirez","sequence":"additional","affiliation":[{"name":"Center for Applied Biotechnology Studies, Department of Biological Science, California State University Fullerton, Fullerton, California, USA"},{"name":"Instituto de Microbiolog\u00eda y Parasitolog\u00eda M\u00e9dica (IMPaM, UBA-CONICET), School of Medicine, UBA, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo E.","family":"Tolmasky","sequence":"additional","affiliation":[{"name":"Center for Applied Biotechnology Studies, Department of Biological Science, California State University Fullerton, Fullerton, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2010.08.003"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2013.00121"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.200900779"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0906529106"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2013.08.016"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.4155\/fmc.13.80"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2011.10.018"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1039\/c003915b"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01099-10"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1001176"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.23394"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.63.12.5037-5045.1989"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.289850"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8137.1978.tb02260.x"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00284-013-0326-5"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01264-09"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.11.3422-3427.2002"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0001800"},{"key":"e_1_3_3_20_2","volume-title":"Molecular cloning: a laboratory manual","author":"Sambrook J","year":"2001","unstructured":"SambrookJFritschEFManiatisT. 2001. Molecular cloning: a laboratory manual, 3rd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.","edition":"3"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201100332"},{"key":"e_1_3_3_22_2","first-page":"712","volume-title":"Kucers' the use of antibiotics","author":"Craig W","year":"2012","unstructured":"CraigW. 2012. Aminoglycosides, p 712\u2013726. In GraysonML (ed), Kucers' the use of antibiotics. CRC Press, Boca Raton, FL."},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00037-09"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1012984713391"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.186.22.7499-7507.2004"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.183.15.4664-4667.2001"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003068"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.3945\/an.112.003210"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.64.5.571"},{"key":"e_1_3_3_30_2","first-page":"153","article-title":"Treatment of the common cold in children and adults","volume":"86","author":"Fashner J","year":"2012","unstructured":"FashnerJEricsonKWernerS. 2012. Treatment of the common cold in children and adults. Am. Fam. Physician 86:153\u2013159.","journal-title":"Am. Fam. Physician"},{"key":"e_1_3_3_31_2","first-page":"CD005436","article-title":"Oral zinc for treating diarrhoea in children","volume":"1","author":"Lazzerini M","year":"2013","unstructured":"LazzeriniMRonfaniL. 2013. Oral zinc for treating diarrhoea in children. Cochrane Database Syst. Rev. 1:CD005436.","journal-title":"Cochrane Database Syst. Rev."},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.3184\/003685013X13587771579987"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-005-0009-5"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00129-14","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00129-14","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T22:52:23Z","timestamp":1645483943000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.00129-14"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7]]},"references-count":32,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["10.1128\/AAC.00129-14"],"URL":"https:\/\/doi.org\/10.1128\/aac.00129-14","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7]]},"assertion":[{"value":"2014-01-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-05-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-06-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}