{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T03:27:08Z","timestamp":1772162828941,"version":"3.50.1"},"reference-count":22,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    We investigated the in vitro activities of posaconazole (POS), fluconazole (FLC), amphotericin B (AMB), and caspofungin (CAS) against four clinical isolates of\n                    <jats:italic>Candida glabrata<\/jats:italic>\n                    with various susceptibilities to FLC (FLC MICs ranging from 1.0 to &gt;64 \u03bcg\/ml). POS MICs ranged from \u22640.03 to 0.5 \u03bcg\/ml; AMB MICs ranged from 0.25 to 2.0 \u03bcg\/ml, while CAS MICs ranged from 0.03 to 0.25 \u03bcg\/ml. When FLC MICs increased, so did POS MICs, although we did not observe any isolate with a POS MIC greater than 0.5 \u03bcg\/ml. Time-kill experiments showed that POS, FLC, and CAS were fungistatic against all isolates, while AMB at eight times the MIC was fungicidal against three out of four isolates of\n                    <jats:italic>C. glabrata<\/jats:italic>\n                    tested. Then, we investigated the activity of POS in an experimental model of disseminated candidiasis using three different isolates of\n                    <jats:italic>C. glabrata<\/jats:italic>\n                    : one susceptible to FLC (S; FLC MICs ranging from 1.0 to 4.0 \u03bcg\/ml; POS MIC of \u22640.03 \u03bcg\/ml), one susceptible in a dose-dependent manner (SDD; FLC MICs ranging from 32 to 64 \u03bcg\/ml; POS MICs ranging from 0.125 to 0.25 \u03bcg\/ml), and another one resistant to FLC (R; FLC MIC of &gt;64 \u03bcg\/ml; POS MIC of 0.5 \u03bcg\/ml). FLC significantly reduced the kidney burden of mice infected with the S strain (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.0070) but not of those infected with the S-DD and R strains. POS was significantly effective against all three isolates at reducing the kidney fungal burden with respect to the controls (\n                    <jats:italic>P<\/jats:italic>\n                    ranging from 0.0003 to 0.029). In conclusion, our data suggest that POS may be a useful option in the management of systemic infections caused by\n                    <jats:italic>C. glabrata<\/jats:italic>\n                    . Additionally, the new triazole may be a therapeutic option in those cases where an FLC-resistant isolate is found to retain a relatively low POS MIC.\n                  <\/jats:p>","DOI":"10.1128\/aac.00130-08","type":"journal-article","created":{"date-parts":[[2008,4,7]],"date-time":"2008-04-07T20:34:48Z","timestamp":1207600488000},"page":"1929-1933","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":12,"title":["Posaconazole against\n                    <i>Candida glabrata<\/i>\n                    Isolates with Various Susceptibilities to Fluconazole"],"prefix":"10.1128","volume":"52","author":[{"given":"Elisabetta","family":"Spreghini","sequence":"first","affiliation":[{"name":"Istituto di Malattie Infettive e Medicina Pubblica"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmelo Massimo","family":"Maida","sequence":"additional","affiliation":[{"name":"Dipartimento di Igiene e Microbiologia D'Alessandro, Universita\u0300 degli Studi di Palermo, Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serena","family":"Tomassetti","sequence":"additional","affiliation":[{"name":"Istituto di Malattie Infettive e Medicina Pubblica"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fiorenza","family":"Orlando","sequence":"additional","affiliation":[{"name":"Dipartimento Ricerche Gerontologiche e Geriatriche N. Masera, I.N.R.C.A. I.R.R.C.S., Ancona"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele","family":"Giannini","sequence":"additional","affiliation":[{"name":"Centro di Gestione Presidenza Medicina e Chirurgia, Universita\u0300 Politecnica delle Marche"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Eleonora","family":"Milici","sequence":"additional","affiliation":[{"name":"Dipartimento di Igiene e Microbiologia D'Alessandro, Universita\u0300 degli Studi di Palermo, Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio","family":"Scalise","sequence":"additional","affiliation":[{"name":"Istituto di Malattie Infettive e Medicina Pubblica"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Barchiesi","sequence":"additional","affiliation":[{"name":"Istituto di Malattie Infettive e Medicina Pubblica"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","first-page":"273","volume":"44","year":"2006","unstructured":"Anstead, G. 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Posaconazole for the treatment of azole-refractory oropharyngeal and esophageal candidiasis in subjects with HIV infection. Clin. Infect. Dis.44:607-614.","journal-title":"Clin. Infect. 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