{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T02:22:43Z","timestamp":1789870963828,"version":"4.0.1"},"reference-count":10,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["1I01BX006885-01A1"],"award-info":[{"award-number":["1I01BX006885-01A1"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2026,9,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      The clinical significance of\n                      <jats:italic toggle=\"yes\">Clostridioides difficile<\/jats:italic>\n                      isolates with reduced fidaxomicin susceptibility is uncertain. We report treatment failure of extended-pulsed fidaxomicin treatment during every other day pulsing associated with emergence of a\n                      <jats:italic toggle=\"yes\">C. difficile<\/jats:italic>\n                      isolate with reduced fidaxomicin susceptibility and a novel\n                      <jats:italic toggle=\"yes\">rpoC<\/jats:italic>\n                      gene mutation, resulting in a novel amino acid substitution (R89K). The reduced susceptibility isolate had no reduction in growth or ability to colonize mice, but\n                      <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                      sporulation and toxin production were reduced.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/aac.00130-26","type":"journal-article","created":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T13:09:51Z","timestamp":1777900191000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":4,"title":["Clinical failure of an extended-pulsed fidaxomicin regimen associated with emergence of a\n                    <i>Clostridioides difficile<\/i>\n                    isolate with reduced fidaxomicin susceptibility in an elderly man"],"prefix":"10.1128","volume":"70","author":[{"given":"Claire E.","family":"Kaple","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/051fd9666","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine","place":["Cleveland, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah N.","family":"Redmond","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/051fd9666","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Medicine, Case Western Reserve University School of Medicine","place":["Cleveland, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L.","family":"Cadnum","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01vrybr67","id-type":"ROR","asserted-by":"publisher"}],"name":"Research Service, Louis Stokes Cleveland VA Medical Center","place":["Cleveland, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan","family":"Hausman","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01vrybr67","id-type":"ROR","asserted-by":"publisher"}],"name":"Research Service, Louis Stokes Cleveland VA Medical Center","place":["Cleveland, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Munok","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Research, Central Texas Veterans Healthcare System","place":["Temple, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8272-9828","authenticated-orcid":true,"given":"Hosoon","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Research, Central Texas Veterans Healthcare System","place":["Temple, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piyali","family":"Chatterjee","sequence":"additional","affiliation":[{"name":"Department of Research, Central Texas Veterans Healthcare System","place":["Temple, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3916-952X","authenticated-orcid":true,"given":"Chetan","family":"Jinadatha","sequence":"additional","affiliation":[{"name":"Department of Medicine, Central Texas Veterans Healthcare System","place":["Temple, USA"]},{"id":[{"id":"https:\/\/ror.org\/01f5ytq51","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Medical Education, College of Medicine, Texas A&M University","place":["Bryan, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0990-4498","authenticated-orcid":true,"given":"Curtis J.","family":"Donskey","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/051fd9666","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Medicine, Case Western Reserve University School of Medicine","place":["Cleveland, USA"]},{"id":[{"id":"https:\/\/ror.org\/01vrybr67","id-type":"ROR","asserted-by":"publisher"}],"name":"Geriatric Research, Education, and Clinical Center, Louis Stokes Cleveland VA Medical Center","place":["Cleveland, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciab549"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2021.09.038"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(17)30751-X"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaf028"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkx486"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkad194"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.01206-24"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0910812"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anaerobe.2025.102992"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkz549"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/aac.00130-26","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/aac.00130-26","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T16:54:56Z","timestamp":1788368096000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/aac.00130-26"}},"subtitle":[],"editor":[{"given":"Cesar A.","family":"Arias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,9,2]]},"references-count":10,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9,2]]}},"alternative-id":["10.1128\/aac.00130-26"],"URL":"https:\/\/doi.org\/10.1128\/aac.00130-26","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,2]]},"assertion":[{"value":"2026-02-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00130-26"}}