{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T03:25:44Z","timestamp":1772162744564,"version":"3.50.1"},"reference-count":25,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T00:00:00Z","timestamp":1746576000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T00:00:00Z","timestamp":1746576000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2025,5,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      Cardiomyopathy is the most common pathology associated with\n                      <jats:italic toggle=\"yes\">Trypanosoma cruzi<\/jats:italic>\n                      infection. Reports that statins have both cardioprotective and trypanocidal activity have generated interest in their potential as a therapeutic treatment. Using a highly sensitive bioluminescent mouse model, we show that a 5-day treatment with statins has no significant impact on parasite load. The free systemic concentrations fail to reach the level required for potency. Hence, clinical trials to investigate the trypanocidal activity of statins lack experimental justification.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/aac.00135-25","type":"journal-article","created":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T09:01:33Z","timestamp":1744621293000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":0,"title":["Statins do not reduce the parasite burden during experimental\n                    <i>Trypanosoma cruzi<\/i>\n                    infection"],"prefix":"10.1128","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7259-701X","authenticated-orcid":true,"given":"Sarah","family":"Razzaq","sequence":"first","affiliation":[{"name":"Department of Infection Biology, London School of Hygiene and Tropical Medicine","place":["London, United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9314-0026","authenticated-orcid":true,"given":"Francisco","family":"Olmo","sequence":"additional","affiliation":[{"name":"Department of Infection Biology, London School of Hygiene and Tropical Medicine","place":["London, United Kingdom"]},{"name":"Department of Parasitology, Faculty of Sciences, University of Granada","place":["Granada, Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9133-3147","authenticated-orcid":true,"given":"Suresh B.","family":"Lakshminarayana","sequence":"additional","affiliation":[{"name":"Global Health, Biomedical Research, Novartis","place":["Emeryville, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Ying-Bo","sequence":"additional","affiliation":[{"name":"Global Health, Biomedical Research, Novartis","place":["Emeryville, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiromani","family":"Jayawardhana","sequence":"additional","affiliation":[{"name":"Department of Infection Biology, London School of Hygiene and Tropical Medicine","place":["London, United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7156-5725","authenticated-orcid":true,"given":"Srinivasa P. 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