{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T17:18:54Z","timestamp":1767979134914,"version":"3.49.0"},"reference-count":11,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[2007,9,1]],"date-time":"2007-09-01T00:00:00Z","timestamp":1188604800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The in vitro and in vivo antipneumococcal activities of the main pneumococcal autolysin (LytA) and Cpl-1, a lysozyme encoded by phage Cp-1, were studied. Intraperitoneal therapy with LytA or high-dose Cpl-1 remarkably reduced peritoneal bacterial counts (&gt;5 log\n            <jats:sub>10<\/jats:sub>\n            CFU\/ml) compared with those for the controls. After intravenous injection, LytA was the most effective treatment.\n          <\/jats:p>","DOI":"10.1128\/aac.00137-07","type":"journal-article","created":{"date-parts":[[2007,6,19]],"date-time":"2007-06-19T00:59:44Z","timestamp":1182214784000},"page":"3371-3373","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":26,"title":["Pneumococcal LytA Autolysin, a Potent Therapeutic Agent in Experimental Peritonitis-Sepsis Caused by Highly \u03b2-Lactam-Resistant\n            <i>Streptococcus pneumoniae<\/i>"],"prefix":"10.1128","volume":"51","author":[{"given":"Violeta","family":"Rodri\u0301guez-Cerrato","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology and Antimicrobial Chemotherapy, Fundacio\u0301n Jime\u0301nez Di\u0301az, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Garci\u0301a","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology, Centro de Investigaciones Biolo\u0301gicas (CSIC), Ramiro de Maeztu 9, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorena","family":"Huelves","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Antimicrobial Chemotherapy, Fundacio\u0301n Jime\u0301nez Di\u0301az, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernesto","family":"Garci\u0301a","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology, Centro de Investigaciones Biolo\u0301gicas (CSIC), Ramiro de Maeztu 9, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gema","family":"del Prado","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Antimicrobial Chemotherapy, Fundacio\u0301n Jime\u0301nez Di\u0301az, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matilde","family":"Gracia","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Antimicrobial Chemotherapy, Fundacio\u0301n Jime\u0301nez Di\u0301az, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Ponte","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Antimicrobial Chemotherapy, Fundacio\u0301n Jime\u0301nez Di\u0301az, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rubens","family":"Lo\u0301pez","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology, Centro de Investigaciones Biolo\u0301gicas (CSIC), Ramiro de Maeztu 9, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Soriano","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Antimicrobial Chemotherapy, Fundacio\u0301n Jime\u0301nez Di\u0301az, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2005.08.007"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.61.8.2573-2580.1987"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.117.2.796-804.1974"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.11.6199-6204.2003"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.1990.tb04019.x"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)63393-9"},{"key":"e_1_3_2_8_2","unstructured":"Approved standard. 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