{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T10:22:59Z","timestamp":1761128579528},"reference-count":23,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Of 1,388\n            <jats:italic>Streptococcus pneumoniae<\/jats:italic>\n            isolates collected from 2000 to 2005, 10.5% had a ciprofloxacin MIC of \u22654.0 \u03bcg\/ml and 1.6% (range, 0.8% to 4.3% per year) had a levofloxacin MIC of \u22654.0 \u03bcg\/ml. Molecular characterization indicated that fluoroquinolone resistance occurred independently in our prevalent Spain\n            <jats:sup>23F<\/jats:sup>\n            -1 clone, expressing serotypes 23F, 19F, and 14. Rates of resistance to levofloxacin in\n            <jats:italic>S. pneumoniae<\/jats:italic>\n            have remained stable at a Hong Kong hospital.\n          <\/jats:p>","DOI":"10.1128\/aac.00139-07","type":"journal-article","created":{"date-parts":[[2007,3,20]],"date-time":"2007-03-20T00:20:22Z","timestamp":1174350022000},"page":"2192-2194","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":21,"title":["Longitudinally Tracking Fluoroquinolone Resistance and Its Determinants in Penicillin-Susceptible and -Nonsusceptible\n            <i>Streptococcus pneumoniae<\/i>\n            Isolates in Hong Kong, 2000 to 2005"],"prefix":"10.1128","volume":"51","author":[{"given":"Margaret","family":"Ip","sequence":"first","affiliation":[{"name":"Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shirley S. L.","family":"Chau","sequence":"additional","affiliation":[{"name":"Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Chi","sequence":"additional","affiliation":[{"name":"Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edmund S. C.","family":"Cheuk","sequence":"additional","affiliation":[{"name":"Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond W. 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