{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T12:55:42Z","timestamp":1775134542668,"version":"3.50.1"},"reference-count":16,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Two new rifabutin analogs, RFA-1 and RFA-2, show high\n            <jats:italic>in vitro<\/jats:italic>\n            antimycobacterial activities against\n            <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n            . MIC values of RFA-1 and RFA-2 were \u22640.02 \u03bcg\/ml against rifamycin-susceptible strains and 0.5 \u03bcg\/ml against a wide selection of multidrug-resistant strains, compared to \u226550 \u03bcg\/ml for rifampin and 10 \u03bcg\/ml for rifabutin. Molecular dynamic studies indicate that the compounds may exert tighter binding to mutants of RNA polymerase that have adapted to the rifamycins.\n          <\/jats:p>","DOI":"10.1128\/aac.00149-10","type":"journal-article","created":{"date-parts":[[2010,9,21]],"date-time":"2010-09-21T04:51:28Z","timestamp":1285044688000},"page":"5363-5365","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":10,"title":["Strong\n            <i>In Vitro<\/i>\n            Activities of Two New Rifabutin Analogs against Multidrug-Resistant\n            <i>Mycobacterium tuberculosis<\/i>"],"prefix":"10.1128","volume":"54","author":[{"given":"Ana-Bele\u0301n","family":"Garci\u0301a","sequence":"first","affiliation":[{"name":"Instituto Universitario de Qui\u0301mica Organometa\u0301lica Enrique Moles, Unidad Asociada al C.S.I.C., Universidad de Oviedo, c\/ Julia\u0301n Claveri\u0301a 8, 33006 Oviedo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan J.","family":"Palacios","sequence":"additional","affiliation":[{"name":"Unidad de Referencia Regional de Micobacterias, Hospital Universitario Central de Asturias, c\/ Doctor Bellmunt s\/n, 33006 Oviedo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mari\u0301a-Jesu\u0301s","family":"Ruiz","sequence":"additional","affiliation":[{"name":"Servicio de Microbiologi\u0301a Cli\u0301nica, Hospital General Universitario Gregorio Maran\u0303o\u0301n, c\/ Dr. Esquerdo 46, 28007 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose\u0301","family":"Barluenga","sequence":"additional","affiliation":[{"name":"Instituto Universitario de Qui\u0301mica Organometa\u0301lica Enrique Moles, Unidad Asociada al C.S.I.C., Universidad de Oviedo, c\/ Julia\u0301n Claveri\u0301a 8, 33006 Oviedo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Aznar","sequence":"additional","affiliation":[{"name":"Instituto Universitario de Qui\u0301mica Organometa\u0301lica Enrique Moles, Unidad Asociada al C.S.I.C., Universidad de Oviedo, c\/ Julia\u0301n Claveri\u0301a 8, 33006 Oviedo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mari\u0301a-Paz","family":"Cabal","sequence":"additional","affiliation":[{"name":"Instituto Universitario de Qui\u0301mica Organometa\u0301lica Enrique Moles, Unidad Asociada al C.S.I.C., Universidad de Oviedo, c\/ Julia\u0301n Claveri\u0301a 8, 33006 Oviedo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose\u0301 Mari\u0301a","family":"Garci\u0301a","sequence":"additional","affiliation":[{"name":"Servicio de Neumologi\u0301a, Hospital San Agusti\u0301n, Camino de Heros 4, 33400 Avile\u0301s, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"Di\u0301az","sequence":"additional","affiliation":[{"name":"Departamento de Qui\u0301mica Fi\u0301sica y Anali\u0301tica, Universidad de Oviedo, c\/ Julia\u0301n Claveri\u0301a 8, 33006 Oviedo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","unstructured":"Spiropiperidyl rifamycins for the treatment of mycobacterial infections. 2007"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2006.08.090"},{"key":"e_1_3_2_4_2","first-page":"1124","year":"2005","unstructured":"Bryskier, A., and J. 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