{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T12:05:01Z","timestamp":1778501101759,"version":"3.51.4"},"reference-count":81,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[2020,8,20]],"date-time":"2020-08-20T00:00:00Z","timestamp":1597881600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,8,20]],"date-time":"2020-08-20T00:00:00Z","timestamp":1597881600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100007729","name":"Dutch Ministry of Foreign Affairs","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007729","id-type":"DOI","asserted-by":"crossref"}]},{"name":"UK Aid"},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004423","name":"World Health Organization","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004423","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001804","name":"Canada Research Chairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001804","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["12I0317N"],"award-info":[{"award-number":["12I0317N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Gouvernement du Canada | Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["G051812N"],"award-info":[{"award-number":["G051812N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007660","name":"Universiteit Antwerpen","doi-asserted-by":"publisher","award":["TT-ZAPBOF 33049"],"award-info":[{"award-number":["TT-ZAPBOF 33049"]}],"id":[{"id":"10.13039\/501100007660","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013996","name":"Global Health Innovative Technology Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013996","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2020,8,20]]},"abstract":"<jats:p>\n            Current antileishmanial treatment is hampered by limitations, such as drug toxicity and the risk of treatment failure, which may be related to parasitic drug resistance. Given the urgent need for novel drugs, the Drugs for Neglected Diseases\n            <jats:italic>initiative<\/jats:italic>\n            (DND\n            <jats:italic>i<\/jats:italic>\n            ) has undertaken a drug discovery program, which has resulted in the identification of aminopyrazoles, a highly promising antileishmanial chemical series. Multiple experiments have been performed to anticipate the propensity for resistance development.\n          <\/jats:p>","DOI":"10.1128\/aac.00152-20","type":"journal-article","created":{"date-parts":[[2020,6,26]],"date-time":"2020-06-26T13:02:40Z","timestamp":1593176560000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":10,"title":["Antileishmanial Aminopyrazoles: Studies into Mechanisms and Stability of Experimental Drug Resistance"],"prefix":"10.1128","volume":"64","author":[{"given":"M.","family":"Van den Kerkhof","sequence":"first","affiliation":[{"name":"Laboratory of Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, Antwerp, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Mabille","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, Antwerp, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Hendrickx","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, Antwerp, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Leprohon","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Infectiologie du Centre de Recherche du Centre Hospitalier Universitaire de Qu\u00e9bec, Universit\u00e9 Laval, Qu\u00e9bec, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. E.","family":"Mowbray","sequence":"additional","affiliation":[{"name":"Drugs for Neglected Diseases initiative (DNDi), Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Braillard","sequence":"additional","affiliation":[{"name":"Drugs for Neglected Diseases initiative (DNDi), Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Ouellette","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Infectiologie du Centre de Recherche du Centre Hospitalier Universitaire de Qu\u00e9bec, Universit\u00e9 Laval, Qu\u00e9bec, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Maes","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, Antwerp, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4870-3202","authenticated-orcid":false,"given":"G.","family":"Caljon","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, Antwerp, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr400552x"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2015.04.006"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/2049936116646063"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003518"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182017002116"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit102"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0100220"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis474"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0005641"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00030-11"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2016.00351"},{"key":"e_1_3_3_13_2","first-page":"201","article-title":"Multidrug resistance and ABC transporters in parasitic protozoa","volume":"3","author":"Ouellette M","year":"2001","unstructured":"Ouellette M, Legare D, Papadopoulou B. 2001. Multidrug resistance and ABC transporters in parasitic protozoa. J Mol Microbiol Biotechnol 3:201\u2013206.","journal-title":"J Mol Microbiol Biotechnol"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10123-001-0031-2"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.5.1988-1993.2005"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M102351200"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01474-08"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpddr.2013.08.001"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2007.05653.x"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00587-08"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkg223"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.539742"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2012.07.100"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00065-11"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00423-06"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00048-18"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S16381"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2015.973850"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpddr.2018.01.006"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1807915115"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005971"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpddr.2019.02.002"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000956"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm0606138"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-06-0355"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2018.10.020"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2016.01.030"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1021\/cb500616x"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00707-15"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-014-3835-7"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2017.06.004"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.47.8.2397-2403.2003"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2011.83"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-015-4460-9"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1586\/14787210.2014.916614"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dky450"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkw096"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2007.01.004"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003948"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012211"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1006117"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-016-5195-y"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0154101"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M308352200"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M605214200"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.mi.45.100191.002221"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0081899"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.123430.111"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkn1069"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/0169-4758(93)90135-3"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2008-9-7-r115"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.13291"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1001868"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.12298"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.12178"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpddr.2018.08.002"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00599-17"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0306-3623(96)00284-4"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2019.105158"},{"key":"e_1_3_3_70_2","doi-asserted-by":"publisher","DOI":"10.1517\/17425255.2016.1168804"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pa.36.040196.001113"},{"key":"e_1_3_3_72_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2000.2680"},{"key":"e_1_3_3_73_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-014-3761-8"},{"key":"e_1_3_3_74_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1984"},{"key":"e_1_3_3_75_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0065467"},{"key":"e_1_3_3_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2006.02.015"},{"key":"e_1_3_3_77_2","doi-asserted-by":"publisher","DOI":"10.2174\/1389450023347588"},{"key":"e_1_3_3_78_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0074862"},{"key":"e_1_3_3_79_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2017.00024"},{"key":"e_1_3_3_80_2","doi-asserted-by":"publisher","DOI":"10.1086\/595710"},{"key":"e_1_3_3_81_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001664"},{"key":"e_1_3_3_82_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00866-09"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00152-20","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00152-20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T22:01:58Z","timestamp":1645480918000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.00152-20"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,20]]},"references-count":81,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,8,20]]}},"alternative-id":["10.1128\/AAC.00152-20"],"URL":"https:\/\/doi.org\/10.1128\/aac.00152-20","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,20]]},"assertion":[{"value":"2020-01-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00152-20"}}