{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T15:46:01Z","timestamp":1790437561539,"version":"4.1.0"},"reference-count":41,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2018,4,26]],"date-time":"2018-04-26T00:00:00Z","timestamp":1524700800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI116420"],"award-info":[{"award-number":["AI116420"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI125770"],"award-info":[{"award-number":["AI125770"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The incidence of invasive fungal infections has risen dramatically in recent decades. Current antifungal drugs are either toxic, likely to interact with other drugs, have a narrow spectrum of activity, or induce fungal resistance. Hence, there is a great need for new antifungals, possibly with novel mechanisms of action. Previously our group reported an acylhydrazone called BHBM that targeted the sphingolipid pathway and showed strong antifungal activity against several fungi. In this study, we screened 19 derivatives of BHBM. Three out of 19 derivatives were highly active against\n                    <jats:named-content content-type=\"genus-species\">Cryptococcus neoformans<\/jats:named-content>\n                    <jats:italic>in vitro<\/jats:italic>\n                    and had low toxicity in mammalian cells. In particular, one of them, called D13, had a high selectivity index and showed better activity in an animal model of cryptococcosis, candidiasis, and pulmonary aspergillosis. D13 also displayed suitable pharmacokinetic properties and was able to pass through the blood-brain barrier. These results suggest that acylhydrazones are promising molecules for the research and development of new antifungal agents.\n                  <\/jats:p>","DOI":"10.1128\/aac.00156-18","type":"journal-article","created":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T08:04:43Z","timestamp":1519891483000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":68,"title":["Acylhydrazones as Antifungal Agents Targeting the Synthesis of Fungal Sphingolipids"],"prefix":"10.1128","volume":"62","author":[{"given":"Cristina","family":"Lazzarini","sequence":"first","affiliation":[{"name":"Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York, USA"},{"name":"Veterans Administration Medical Center, Northport, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krupanandan","family":"Haranahalli","sequence":"additional","affiliation":[{"name":"Institute of Chemical Biology and Drug Discovery, Stony Brook University, Stony Brook, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Rieger","sequence":"additional","affiliation":[{"name":"Proteomics Center, Stony Brook University, Stony Brook, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hari Krishna","family":"Ananthula","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, University of Cincinnati, Cincinnati, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pankaj B.","family":"Desai","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, University of Cincinnati, Cincinnati, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Ashbaugh","sequence":"additional","affiliation":[{"name":"Department of Veterans Affairs Medical Center, Cincinnati, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Linke","sequence":"additional","affiliation":[{"name":"Department of Veterans Affairs Medical Center, Cincinnati, Ohio, USA"},{"name":"University of Cincinnati College of Medicine, Cincinnati, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie T.","family":"Cushion","sequence":"additional","affiliation":[{"name":"Department of Veterans Affairs Medical Center, Cincinnati, Ohio, USA"},{"name":"University of Cincinnati College of Medicine, Cincinnati, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bela","family":"Ruzsicska","sequence":"additional","affiliation":[{"name":"Institute of Chemical Biology and Drug Discovery, Stony Brook University, Stony Brook, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Haley","sequence":"additional","affiliation":[{"name":"Institute of Chemical Biology and Drug Discovery, Stony Brook University, Stony Brook, New York, USA"},{"name":"Proteomics Center, Stony Brook University, Stony Brook, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iwao","family":"Ojima","sequence":"additional","affiliation":[{"name":"Institute of Chemical Biology and Drug Discovery, Stony Brook University, Stony Brook, New York, USA"},{"name":"Department of Chemistry, Stony Brook University, Stony Brook, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Del Poeta","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York, USA"},{"name":"Veterans Administration Medical Center, Northport, New York, USA"},{"name":"Institute of Chemical Biology and Drug Discovery, Stony Brook University, Stony Brook, New York, USA"},{"name":"Division of Infectious Diseases, School of Medicine, Stony Brook University, Stony Brook, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3109\/10408410903241444"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(03)00802-8"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-62703-257-5_1"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3004404"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2014.01.001"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-013-1867-1"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1086\/592690"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1086\/496922"},{"key":"e_1_3_3_10_2","first-page":"595","volume-title":"Cryptococcus: from human pathogen to model yeast","author":"Sorrell TC","year":"2011","unstructured":"Sorrell TC, Chen SC-A, Phillips P, Marr KA. 2011. 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