{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:47:33Z","timestamp":1791308853145,"version":"4.3.1"},"reference-count":37,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2006,6,1]],"date-time":"2006-06-01T00:00:00Z","timestamp":1149120000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The in vitro activity of the novel triazole antifungal agent posaconazole (Noxafil; SCH 56592) was assessed in 45 laboratories against approximately 19,000 clinically important strains of yeasts and molds. The activity of posaconazole was compared with those of itraconazole, fluconazole, voriconazole, and amphotericin B against subsets of the isolates. Strains were tested utilizing Clinical and Laboratory Standards Institute broth microdilution methods using RPMI 1640 medium (except for amphotericin B, which was frequently tested in antibiotic medium 3). MICs were determined at the recommended endpoints and time intervals. Against all fungi in the database (22,850 MICs), the MIC\n                    <jats:sub>50<\/jats:sub>\n                    and MIC\n                    <jats:sub>90<\/jats:sub>\n                    values for posaconazole were 0.063 \u03bcg\/ml and 1 \u03bcg\/ml, respectively. MIC\n                    <jats:sub>90<\/jats:sub>\n                    values against all yeasts (18,351 MICs) and molds (4,499 MICs) were both 1 \u03bcg\/ml. In comparative studies against subsets of the isolates, posaconazole was more active than, or within 1 dilution of, the comparator drugs itraconazole, fluconazole, voriconazole, and amphotericin B against approximately 7,000 isolates of\n                    <jats:italic>Candida<\/jats:italic>\n                    and\n                    <jats:italic>Cryptococcus<\/jats:italic>\n                    spp. Against all molds (1,702 MICs, including 1,423 MICs for\n                    <jats:italic>Aspergillus<\/jats:italic>\n                    isolates), posaconazole was more active than or equal to the comparator drugs in almost every category. Posaconazole was active against isolates of\n                    <jats:italic>Candida<\/jats:italic>\n                    and\n                    <jats:italic>Aspergillus<\/jats:italic>\n                    spp. that exhibit resistance to fluconazole, voriconazole, and amphotericin B and was much more active than the other triazoles against zygomycetes. Posaconazole exhibited potent antifungal activity against a wide variety of clinically important fungal pathogens and was frequently more active than other azoles and amphotericin B.\n                  <\/jats:p>","DOI":"10.1128\/aac.00163-06","type":"journal-article","created":{"date-parts":[[2006,5,24]],"date-time":"2006-05-24T17:13:58Z","timestamp":1148490838000},"page":"2009-2015","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":387,"title":["In Vitro Activities of Posaconazole, Fluconazole, Itraconazole, Voriconazole, and Amphotericin B against a Large Collection of Clinically Important Molds and Yeasts"],"prefix":"10.1128","volume":"50","author":[{"given":"F.","family":"Sabatelli","sequence":"first","affiliation":[{"name":"Schering-Plough Research Institute, Kenilworth, New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Patel","sequence":"additional","affiliation":[{"name":"Schering-Plough Research Institute, Kenilworth, New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. A.","family":"Mann","sequence":"additional","affiliation":[{"name":"Schering-Plough Research Institute, Kenilworth, New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. A.","family":"Mendrick","sequence":"additional","affiliation":[{"name":"Schering-Plough Research Institute, Kenilworth, New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. C.","family":"Norris","sequence":"additional","affiliation":[{"name":"Schering-Plough Research Institute, Kenilworth, New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Hare","sequence":"additional","affiliation":[{"name":"Schering-Plough Research Institute, Kenilworth, New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Loebenberg","sequence":"additional","affiliation":[{"name":"Schering-Plough Research Institute, Kenilworth, New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. A.","family":"Black","sequence":"additional","affiliation":[{"name":"Schering-Plough Research Institute, Kenilworth, New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. M.","family":"McNicholas","sequence":"additional","affiliation":[{"name":"Schering-Plough Research Institute, Kenilworth, New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.1.226-229.2000"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/167.5.1247"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200464180-00001"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.8.2017-2022.2000"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.7.2151-2153.2001"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.6.2124-2131.2004"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkg020"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dki140"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.5.1352-1356.2002"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.50.1.126-133.2006"},{"key":"e_1_3_2_12_2","first-page":"1451","volume":"23","year":"2003","unstructured":"Herbrecht, R., R. Kessler, C. Kravanja, M. H. Meyer, J. Waller, and V. Letscher-Bru. 2003. Successful treatment of Fusarium proliferatum pneumonia with posaconazole in a lung transplant recipient. J. Heart Lung Transplant.23:1451-1454.","journal-title":"J. Heart Lung Transplant."},{"key":"e_1_3_2_13_2","first-page":"1553","volume":"11","year":"2005","unstructured":"Keating, G. M. 2005. Posaconazole. Drugs11:1553-1567.","journal-title":"Drugs"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.10.2310"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkh027"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1465-0691.2004.1004.x"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/46.2.229"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1086\/322606"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.1.62-68.2002"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.10.3690-3696.2004"},{"key":"e_1_3_2_21_2","unstructured":"National Committee for Clinical Laboratory Standards. 2002. Reference method for broth dilution antifungal susceptibility testing of filamentous fungi. Approved standard M38-A. 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Pharm."}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00163-06","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00163-06","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T14:09:39Z","timestamp":1645452579000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.00163-06"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,6]]},"references-count":37,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2006,6]]}},"alternative-id":["10.1128\/AAC.00163-06"],"URL":"https:\/\/doi.org\/10.1128\/aac.00163-06","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1040664.489678","asserted-by":"object"}]},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,6]]},"assertion":[{"value":"2006-02-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2006-04-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2006-06-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}