{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T23:25:16Z","timestamp":1789601116917,"version":"build-2803163510"},"reference-count":11,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:p>\n                    VL-2397, a novel, systemic antifungal agent, has potent\n                    <jats:italic>in vitro<\/jats:italic>\n                    and\n                    <jats:italic>in vivo<\/jats:italic>\n                    fungicidal activity against\n                    <jats:italic>Aspergillus<\/jats:italic>\n                    species. Plasma concentrations from a phase 1 study were used to construct a population pharmacokinetic (PPK) model for VL-2397.\n                  <\/jats:p>","DOI":"10.1128\/aac.00163-19","type":"journal-article","created":{"date-parts":[[2019,4,10]],"date-time":"2019-04-10T06:37:27Z","timestamp":1554878247000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":17,"title":["Population Pharmacokinetic Modeling of VL-2397, a Novel Systemic Antifungal Agent: Analysis of a Single- and Multiple-Ascending-Dose Study in Healthy Subjects"],"prefix":"10.1128","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4493-4652","authenticated-orcid":false,"given":"Laura L.","family":"Kovanda","sequence":"first","affiliation":[{"name":"Astellas Pharma Global Development, Inc., Northbrook, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean M.","family":"Sullivan","sequence":"additional","affiliation":[{"name":"Vical Incorporated, San Diego, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry R.","family":"Smith","sequence":"additional","affiliation":[{"name":"Vical Incorporated, San Diego, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit V.","family":"Desai","sequence":"additional","affiliation":[{"name":"Astellas Pharma Global Development, Inc., Northbrook, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pete L.","family":"Bonate","sequence":"additional","affiliation":[{"name":"Astellas Pharma Global Development, Inc., Northbrook, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6187-878X","authenticated-orcid":false,"given":"William W.","family":"Hope","sequence":"additional","affiliation":[{"name":"University of Liverpool, Liverpool, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2015.10.015"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2015.10.012"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1358\/dot.2015.51.12.2421058"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/ja.2016.106"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/ja.2016.107"},{"key":"e_1_3_2_7_2","unstructured":"Nakamura I Ohsumi K Yoshikawa K Kanasaki R Masaki T Takase S Hashimoto M Fujie A Nakai T Matsumoto S Takeda S Akamatsu S Uchida S Maki K. 2015. ASP2397: a novel natural product with potent fungicidal activity against Aspergillus spp. (1) A new mode of action and in vitro activity. Abstr 54th Intersci Conf Antimicrob Chemother abstr F-1590."},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00239-004-0218-1"},{"key":"e_1_3_2_9_2","unstructured":"Nakamura I Nakai T Matsumoto S Takeda S Akamatsu S Uchida S Koide Y Mitori H Noto T Maki K. 2015. ASP2397: a novel natural product with potent fungicidal activity against Aspergillus spp. (2)\u2013in vivo activity against A. fumigatus. Abstr 54th Intersci Conf Antimicrob Chemother abstr F-1591."},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1517\/17425250902992901"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0b013e31825c4ba6"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1006\/jcph.2002.6995"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00163-19","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00163-19","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T16:25:26Z","timestamp":1645460726000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.00163-19"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":11,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["10.1128\/AAC.00163-19"],"URL":"https:\/\/doi.org\/10.1128\/aac.00163-19","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"2019-01-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00163-19"}}