{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T04:04:16Z","timestamp":1792728256808,"version":"4.5.0"},"reference-count":32,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T00:00:00Z","timestamp":1754438400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T00:00:00Z","timestamp":1754438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2025,8,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      Clinical evidence is lacking regarding the efficacy of aztreonam-avibactam in severe infections involving\n                      <jats:italic toggle=\"yes\">Stenotrophomonas maltophilia<\/jats:italic>\n                      . We report a case of post-neurosurgical meningitis due to\n                      <jats:italic toggle=\"yes\">S. maltophilia<\/jats:italic>\n                      (minimal inhibitory concentration of aztreonam plus avibactam, 4\/4 \u00b5g\/mL) clinically and microbiologically cured with a combination of aztreonam and ceftazidime-avibactam (2 g and 2 g\/500 mg q8h, 3 h simultaneous infusions). Therapeutic drug monitoring showed adequate concentrations of aztreonam and avibactam in the cerebrospinal fluid at each time point over the 14-day treatment duration.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/aac.00172-25","type":"journal-article","created":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T10:14:01Z","timestamp":1748859241000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":7,"title":["Aztreonam plus ceftazidime-avibactam for post-neurosurgical meningitis due to\n                    <i>Stenotrophomonas maltophilia<\/i>"],"prefix":"10.1128","volume":"69","author":[{"given":"Jonathan","family":"Wong-So","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04yvax419","id-type":"ROR","asserted-by":"publisher"}],"name":"Service de M\u00e9decine Intensive R\u00e9animation, Centre Hospitalier Universitaire d'Orleans","place":["Orl\u00e9ans, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Magr\u00e9ault","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00pg5jh14","id-type":"ROR","asserted-by":"publisher"}],"name":"Laboratoire de Pharmacologie, H\u00f4pital Jean Verdier, Assistance Publique-H\u00f4pitaux de Paris","place":["Paris, France"]},{"id":[{"id":"https:\/\/ror.org\/0199hds37","id-type":"ROR","asserted-by":"publisher"}],"name":"\u00c9quipe IAME, INSERM, Universit\u00e9 Sorbonne Paris Nord","place":["Bobigny, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9tienne","family":"Carbonnelle","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04yvax419","id-type":"ROR","asserted-by":"publisher"}],"name":"Laboratoire de Microbiologie, Centre Hospitalier Universitaire d'Orleans","place":["Orl\u00e9ans, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Jullien","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00pg5jh14","id-type":"ROR","asserted-by":"publisher"}],"name":"Laboratoire de Pharmacologie, H\u00f4pital Jean Verdier, Assistance Publique-H\u00f4pitaux de Paris","place":["Paris, France"]},{"id":[{"id":"https:\/\/ror.org\/0199hds37","id-type":"ROR","asserted-by":"publisher"}],"name":"\u00c9quipe IAME, INSERM, Universit\u00e9 Sorbonne Paris Nord","place":["Bobigny, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Desgrouas","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04yvax419","id-type":"ROR","asserted-by":"publisher"}],"name":"Service de M\u00e9decine Intensive R\u00e9animation, Centre Hospitalier Universitaire d'Orleans","place":["Orl\u00e9ans, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Boulain","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04yvax419","id-type":"ROR","asserted-by":"publisher"}],"name":"Service de M\u00e9decine Intensive R\u00e9animation, Centre Hospitalier Universitaire d'Orleans","place":["Orl\u00e9ans, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8447-7265","authenticated-orcid":true,"given":"Fran\u00e7ois","family":"Barbier","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04yvax419","id-type":"ROR","asserted-by":"publisher"}],"name":"Service de M\u00e9decine Intensive R\u00e9animation, Centre Hospitalier Universitaire d'Orleans","place":["Orl\u00e9ans, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-023-01153-6"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00777-17"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01433-20"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciae403"},{"key":"e_1_3_2_6_2","unstructured":"European Society of Clinical Microbiology and Infectious diseases. 2024. 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