{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:59:36Z","timestamp":1792004376071,"version":"4.4.0"},"reference-count":12,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100009032","name":"Pfizer UK","doi-asserted-by":"publisher","award":["ISR 94296753"],"award-info":[{"award-number":["ISR 94296753"]}],"id":[{"id":"10.13039\/100009032","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2026,5,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      We evaluated the\n                      <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                      activity of aztreonam-avibactam and other agents against 593 metallo-\u03b2-lactamase (MBL)-producing Enterobacterales collected in France in 2024. Aztreonam-avibactam showed the highest activity (98% susceptible), with resistance mainly observed in NDM-5-producing\n                      <jats:italic toggle=\"yes\">Escherichia coli<\/jats:italic>\n                      belonging to ST167, ST405, and ST361. Cefepime-zidebactam also exhibited strong activity (96.6% of susceptibility). Cefepime-taniborbactam and cefiderocol showed reduced overall activity (76.4% and 74.9% susceptibility, respectively), with reduced efficacy mainly observed among NDM-producing isolates. Comparison with 1,465 isolates from 2023 showed no increase in aztreonam-avibactam resistance.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/aac.00176-26","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T14:09:46Z","timestamp":1774620586000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":5,"title":["Comparative\n                    <i>in vitro<\/i>\n                    efficacy of aztreonam-avibactam and other alternatives (cefepime-taniborbactam, cefepime-zidebactam, and cefiderocol) against metallo-\u03b2-lactamase-producing Enterobacterales isolated in 2024 in France"],"prefix":"10.1128","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-3595-6434","authenticated-orcid":true,"given":"C\u00e9cile","family":"Emeraud","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02vjkv261","id-type":"ROR","asserted-by":"publisher"}],"name":"Team \"Resist\" UMR1184 Immunology of Viral, Auto-Immune, Hematological and Bacterial Diseases (IMVA-HB), INSERM, Universit\u00e9 Paris-Saclay, CEA, LabEx LERMIT, Faculty of Medicine","place":["Le Kremlin-Bic\u00eatre, France"]},{"name":"Bacteriology-Hygiene Unit, Bic\u00eatre Hospital, Assistance Publique-H\u00f4pitaux de Paris (APHP)","place":["Le Kremlin-Bic\u00eatre, France"]},{"name":"Associated French National Reference Center for Antibiotic Resistance: Carbapenemase-Producing Enterobacteriaceae","place":["Le Kremlin-Bic\u00eatre, France"]},{"id":[{"id":"https:\/\/ror.org\/04bpvsh10","id-type":"ROR","asserted-by":"publisher"}],"name":"SEPSIS Comprehensive Center\u2013IHU SEPSIS","place":["Garches, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7198-1061","authenticated-orcid":true,"given":"Marion","family":"Dutkiewicz","sequence":"additional","affiliation":[{"name":"Bacteriology-Hygiene Unit, Bic\u00eatre Hospital, Assistance Publique-H\u00f4pitaux de Paris (APHP)","place":["Le Kremlin-Bic\u00eatre, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6596-7384","authenticated-orcid":true,"given":"Laurent","family":"Dortet","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02vjkv261","id-type":"ROR","asserted-by":"publisher"}],"name":"Team \"Resist\" UMR1184 Immunology of Viral, Auto-Immune, Hematological and Bacterial Diseases (IMVA-HB), INSERM, Universit\u00e9 Paris-Saclay, CEA, LabEx LERMIT, Faculty of Medicine","place":["Le Kremlin-Bic\u00eatre, France"]},{"name":"Bacteriology-Hygiene Unit, Bic\u00eatre Hospital, Assistance Publique-H\u00f4pitaux de Paris (APHP)","place":["Le Kremlin-Bic\u00eatre, France"]},{"name":"Associated French National Reference Center for Antibiotic Resistance: Carbapenemase-Producing Enterobacteriaceae","place":["Le Kremlin-Bic\u00eatre, France"]},{"id":[{"id":"https:\/\/ror.org\/04bpvsh10","id-type":"ROR","asserted-by":"publisher"}],"name":"SEPSIS Comprehensive Center\u2013IHU SEPSIS","place":["Garches, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-024-02102-8"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.04936-22"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/jacamr\/dlae141"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkaa021"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofad276"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.00311-22"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00389-17"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01659-20"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid3010.240814"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/jacamr\/dlaa081"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40121-023-00773-6"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2023.28.42.2300095"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/aac.00176-26","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/aac.00176-26","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T13:03:52Z","timestamp":1778072632000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/aac.00176-26"}},"subtitle":[],"editor":[{"given":"Alessandra","family":"Carattoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,5,6]]},"references-count":12,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5,6]]}},"alternative-id":["10.1128\/aac.00176-26"],"URL":"https:\/\/doi.org\/10.1128\/aac.00176-26","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,6]]},"assertion":[{"value":"2026-02-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00176-26"}}