{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T07:01:19Z","timestamp":1771657279073,"version":"3.50.1"},"reference-count":45,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[2008,9,1]],"date-time":"2008-09-01T00:00:00Z","timestamp":1220227200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2008,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Listeriosis is a rare but life-threatening infection. A favorable outcome is greatly aided by early administration of antibiotics with rapid bactericidal activity against\n            <jats:italic>Listeria monocytogenes<\/jats:italic>\n            . Moxifloxacin, a new-generation fluoroquinolone with extended activity against gram-positive bacteria, has proved its effectiveness in vitro against intracellular reservoirs of bacteria. The efficacies of moxifloxacin and amoxicillin were compared in vivo by survival curve assays and by studying the kinetics of bacterial growth in blood and organs in a murine model of central nervous system (CNS) listeriosis. We combined pharmacokinetic and pharmacodynamic approaches to correlate the observed efficacy in vivo with plasma and tissue moxifloxacin concentrations. Death was significantly delayed for animals treated with a single dose of moxifloxacin compared to a single dose of amoxicillin. We observed rapid bacterial clearance from blood and organs of animals treated with moxifloxacin. The decrease in the bacterial counts in blood and brain correlated with plasma and cerebral concentrations of antibiotic. Moxifloxacin peaked in the brain at 1.92 \u00b1 0.32 \u03bcg\/g 1 hour after intraperitoneal injection. This suggests that moxifloxacin rapidly crosses the blood-brain barrier and diffuses into the cerebral parenchyma. Moreover, no resistant strains were selected during in vivo experiments. Our results indicate that moxifloxacin combines useful pharmacokinetic properties and rapid bactericidal activity and that it may be a valuable alternative for the treatment of CNS listeriosis.\n          <\/jats:p>","DOI":"10.1128\/aac.00177-08","type":"journal-article","created":{"date-parts":[[2008,6,24]],"date-time":"2008-06-24T01:07:28Z","timestamp":1214269648000},"page":"3210-3215","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":14,"title":["Rapid Eradication of\n            <i>Listeria monocytogenes<\/i>\n            by Moxifloxacin in a Murine Model of Central Nervous System Listeriosis"],"prefix":"10.1128","volume":"52","author":[{"given":"Sole\u0300ne","family":"Grayo","sequence":"first","affiliation":[{"name":"Laboratoire de Listeria, Centre National de Re\u0301fe\u0301rence des Listeria and World Health Organization Collaborating Centre for Foodborne Listeriosis, Institut Pasteur, 25 rue du Dr Roux, 75015 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Catherine","family":"Lott-Desroches","sequence":"additional","affiliation":[{"name":"Laboratoire de Suivi The\u0301rapeutique et de Contro\u0302le des Me\u0301dicaments, Service de Pharmacie, Ho\u0302pital Necker-Enfants Malades, Assistance Publique-Ho\u0302pitaux de Paris (AP-HP), 149 rue de Se\u0300vres, 75015 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Dussurget","sequence":"additional","affiliation":[{"name":"Unite\u0301 des Interactions Bacte\u0301ries-Cellules, Institut Pasteur, 25 rue du Dr Roux, 75015 Paris, France"},{"name":"INSERM U604, 25 rue du Dr Roux, 75015 Paris, France"},{"name":"INRA USC2020, 25 rue du Dr Roux, 75015 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renaud","family":"Respaud","sequence":"additional","affiliation":[{"name":"Laboratoire de Suivi The\u0301rapeutique et de Contro\u0302le des Me\u0301dicaments, Service de Pharmacie, Ho\u0302pital Necker-Enfants Malades, Assistance Publique-Ho\u0302pitaux de Paris (AP-HP), 149 rue de Se\u0300vres, 75015 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnaud","family":"Fontanet","sequence":"additional","affiliation":[{"name":"Unite\u0301 d'Epide\u0301miologie des Maladies Emergentes, 25 rue du Dr Roux, Institut Pasteur, 75015 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Join-Lambert","sequence":"additional","affiliation":[{"name":"Unite\u0301 INSERM U570, Universite\u0301 Paris Descartes, Faculte\u0301 de Me\u0301decine, Site Necker, 156 rue de Vaugirard, 75015 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Singlas","sequence":"additional","affiliation":[{"name":"Laboratoire de Suivi The\u0301rapeutique et de Contro\u0302le des Me\u0301dicaments, Service de Pharmacie, Ho\u0302pital Necker-Enfants Malades, Assistance Publique-Ho\u0302pitaux de Paris (AP-HP), 149 rue de Se\u0300vres, 75015 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alban","family":"Le Monnier","sequence":"additional","affiliation":[{"name":"Laboratoire de Listeria, Centre National de Re\u0301fe\u0301rence des Listeria and World Health Organization Collaborating Centre for Foodborne Listeriosis, Institut Pasteur, 25 rue du Dr Roux, 75015 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","unstructured":"Guidance for industry bioanalytical method validation. 2001"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365540110080430"},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1093\/jac\/44.4.565","volume":"44","year":"1999","unstructured":"Blanot, S., C. 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