{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T09:10:53Z","timestamp":1791277853656,"version":"4.1.0"},"reference-count":19,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2009,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            We determined the prevalence of fluoroquinolone resistance among the isolates of\n            <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n            from 605 pulmonary tuberculosis patients in Shanghai, China. Mutations in\n            <jats:italic>gyrA<\/jats:italic>\n            were found in 81.5% of phenotypically fluoroquinolone-resistant isolates and were used as a molecular marker of fluoroquinolone resistance.\n            <jats:italic>gyrA<\/jats:italic>\n            mutations were detected in 1.9% of strains pan-susceptible to first-line drugs and 25.1% of multidrug-resistant strains. Fluoroquinolone resistance was independently associated with resistance to at least one first-line drug and prior tuberculosis treatment.\n          <\/jats:p>","DOI":"10.1128\/aac.00177-09","type":"journal-article","created":{"date-parts":[[2009,4,14]],"date-time":"2009-04-14T00:33:44Z","timestamp":1239669224000},"page":"3170-3172","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":39,"title":["Prevalence of Fluoroquinolone Resistance among Tuberculosis Patients in Shanghai, China"],"prefix":"10.1128","volume":"53","author":[{"given":"Peng","family":"Xu","sequence":"first","affiliation":[{"name":"Department of TB Control, Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China"},{"name":"Key Laboratory of Medical Molecular Virology, Institutes of Biomedical Sciences and Institute of Medical Microbiology, Fudan University, Shanghai 200032, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Medical Molecular Virology, Institutes of Biomedical Sciences and Institute of Medical Microbiology, Fudan University, Shanghai 200032, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of TB Control, Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China"},{"name":"Key Laboratory of Medical Molecular Virology, Institutes of Biomedical Sciences and Institute of Medical Microbiology, Fudan University, Shanghai 200032, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Gui","sequence":"additional","affiliation":[{"name":"Department of TB Control, Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn","family":"DeRiemer","sequence":"additional","affiliation":[{"name":"School of Medicine, University of California, One Shields Avenue, Davis, California 95616"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastien","family":"Gagneux","sequence":"additional","affiliation":[{"name":"Division of Mycobacterial Research, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Mei","sequence":"additional","affiliation":[{"name":"Department of TB Control, Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Gao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Medical Molecular Virology, Institutes of Biomedical Sciences and Institute of Medical Microbiology, Fudan University, Shanghai 200032, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.39.8.1700"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","first-page":"9","DOI":"10.2165\/00003495-200161010-00002","volume":"61","year":"2001","unstructured":"Berning, S. 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Antimicrobial susceptibility testing of Mycobacterium tuberculosis (EUCAST document E.DEF 8.1)\u2014report of the Subcommittee on Antimicrobial Susceptibility Testing of Mycobacterium tuberculosis of the European Committee for Antimicrobial Susceptibility Testing (EUCAST) of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID). Clin. Microbiol. Infect.13:1144-1156.","journal-title":"Clin. Microbiol. 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