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There are relatively few therapeutic options, and there is undue reliance on carbapenems. Alternative therapeutic options are urgently required. A combination of cefepime and the novel beta lactamase inhibitor enmetazobactam is being developed for the treatment of serious infections caused by ESBL-producing organisms. The pharmacokinetics-pharmacodynamics (PK-PD) of cefepime-enmetazobactam against ESBL-producing\n            <jats:named-content content-type=\"genus-species\">K. pneumoniae<\/jats:named-content>\n            was studied in a neutropenic murine pneumonia model.\n          <\/jats:p>","DOI":"10.1128\/aac.00180-20","type":"journal-article","created":{"date-parts":[[2020,4,2]],"date-time":"2020-04-02T22:21:30Z","timestamp":1585866090000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":42,"title":["Pharmacodynamics of Cefepime Combined with the Novel Extended-Spectrum-\u03b2-Lactamase (ESBL) Inhibitor Enmetazobactam for Murine Pneumonia Caused by ESBL-Producing\n            <i>Klebsiella pneumoniae<\/i>"],"prefix":"10.1128","volume":"64","author":[{"given":"Adam","family":"Johnson","sequence":"first","affiliation":[{"name":"Antimicrobial Pharmacodynamics and Therapeutics, University of Liverpool, Liverpool Health 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