{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:08:07Z","timestamp":1791331687528,"version":"4.3.1"},"reference-count":12,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T00:00:00Z","timestamp":1652745600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1128\/ASMCopyrightv2"},{"start":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T00:00:00Z","timestamp":1652745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["GR-2018-12367572"],"award-info":[{"award-number":["GR-2018-12367572"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2022,5,17]]},"abstract":"<jats:p>\n            Herein, we report the\n            <jats:italic>in vivo<\/jats:italic>\n            evolution of imipenem\/relebactam-resistance in KPC-producing\n            <jats:named-content content-type=\"genus-species\">K. pneumoniae<\/jats:named-content>\n            (KPC-Kp) isolated from a critically-ill patient treated with multiple combination therapies based on ceftazidime-avibactam or meropenem-vaborbactam. Imipenem\/relebactam-resistance was associated to meropenem-vaborbactam cross-resistance and was due to truncated OmpK35 and OmpK36 porins and increased copy of\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>KPC<\/jats:sub>\n            copy number.\n          <\/jats:p>","DOI":"10.1128\/aac.00191-22","type":"journal-article","created":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T13:01:11Z","timestamp":1649854871000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":48,"title":["Increased\n            <i>bla<\/i>\n            <sub>KPC<\/sub>\n            Copy Number and OmpK35 and OmpK36 Porins Disruption Mediated Resistance to Imipenem\/Relebactam and Meropenem\/Vaborbactam in a KPC-Producing Klebsiella pneumoniae Clinical 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