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Furthermore, we illustrate that the sigma factor (\u03c3\n            <jats:sup>70<\/jats:sup>\n            ) surprisingly increases the transcription efficiency of templates with nonphysiological nonprokaryotic promoters. Our results might be a useful guideline in the early stages of using RNAP for drug discovery.\n          <\/jats:p>","DOI":"10.1128\/aac.00198-12","type":"journal-article","created":{"date-parts":[[2012,6,5]],"date-time":"2012-06-05T09:54:33Z","timestamp":1338890073000},"page":"4536-4539","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":9,"title":["Influence of DNA Template Choice on Transcription and Inhibition of Escherichia coli RNA Polymerase"],"prefix":"10.1128","volume":"56","author":[{"given":"Joerg","family":"Haupenthal","sequence":"first","affiliation":[{"name":"Helmholtz Institute for Pharmaceutical Research Saarland, Saarbr\u00fccken, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina","family":"H\u00fcsecken","sequence":"additional","affiliation":[{"name":"Helmholtz Institute for Pharmaceutical Research Saarland, Saarbr\u00fccken, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Negri","sequence":"additional","affiliation":[{"name":"Helmholtz Institute for Pharmaceutical Research Saarland, Saarbr\u00fccken, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine K.","family":"Maurer","sequence":"additional","affiliation":[{"name":"Helmholtz Institute for Pharmaceutical Research Saarland, Saarbr\u00fccken, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rolf W.","family":"Hartmann","sequence":"additional","affiliation":[{"name":"Helmholtz Institute for Pharmaceutical Research Saarland, Saarbr\u00fccken, Germany"},{"name":"Pharmaceutical and Medicinal Chemistry, Saarland University, Saarbr\u00fccken, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1779"},{"key":"e_1_3_3_3_2","doi-asserted-by":"crossref","first-page":"13179","DOI":"10.1016\/S0021-9258(17)36816-3","article-title":"A mismatch bubble in double-stranded DNA suffices to direct precise transcription initiation by Escherichia coli RNA polymerase","volume":"269","author":"Aiyar SE","year":"1994","unstructured":"AiyarSE HelmannJD deHasethPL. 1994. 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