{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:27:03Z","timestamp":1792787223774,"version":"4.5.0"},"reference-count":43,"publisher":"American Society for Microbiology","issue":"10","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"Wellcome Trust","award":["222754\/Z\/21\/Z"],"award-info":[{"award-number":["222754\/Z\/21\/Z"]}],"id":[{"id":"https:\/\/ror.org\/029chgv08","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2026,10,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      Chagas disease, caused by\n                      <jats:italic toggle=\"yes\">Trypanosoma cruzi<\/jats:italic>\n                      , is endemic to the Americas but has spread worldwide due to migration. Benznidazole is effective, but long-term follow-up efficacy studies are scarce and include only small numbers of patients. We analyzed data from a retrospective cohort of Chagas disease patients treated with benznidazole at a large tertiary center in Argentina (1980\u20132019). Treatment response was assessed through clinical, parasitological, and serological follow-up. Parasitemia was evaluated by direct visualization or PCR. Among 567 treated patients, 464 met selection criteria, including 411 children (median age: 46 months, IQR: 9.5\u2013124 months) and 53 adults (median age: 26 years, IQR: 20\u201334 years). At diagnosis, 11\/411 (2.68%) children and 1\/53 (1.9%) adults were symptomatic; all improved after treatment. Baseline parasitemia was detected in 289\/445 (64.94%) of patients, and 279\/289 (96.54%) had parasitological follow-up for at least 3 years. Median benznidazole dose was 6.6 mg\/kg\/day in children and 5.6 mg\/kg\/day in adults, with treatment durations of 8 weeks and 31 days, respectively. All patients cleared parasitemia at treatment completion. Median serological follow-up was 4.8 years for children and 2.8 years for adults. At 1-year follow-up, 38.8% of patients showed &gt;20% reduction in\n                      <jats:italic toggle=\"yes\">T. cruzi<\/jats:italic>\n                      antibody titers, and 29.8% achieved seronegativity, with younger patients converting faster (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.01). In this Argentinian cohort, Benznidazole achieved sustained parasitemia clearance and declining antibody titers, supporting early treatment initiation.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/aac.00203-26","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T14:04:52Z","timestamp":1789135492000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":0,"title":["Effectiveness of benznidazole in the treatment of Chagas disease in children and adults: a long-term retrospective cohort study"],"prefix":"10.1128","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9291-9078","authenticated-orcid":true,"given":"A.","family":"Rabinovich","sequence":"first","affiliation":[{"name":"Servicio de Parasitolog\u00eda and Instituto Multidisciplinario de Investigaciones en Patolog\u00edas Pedi\u00e1tricas (IMIPP), CONICET-GCBA, Hospital de Ni\u00f1os Ricardo Gutierrez","place":["Buenos Aires, Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8393-8536","authenticated-orcid":false,"given":"C.","family":"Cruz","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology and Toxicology, Department of Pediatrics, Sickkids, The Hospital for Sick Children, University of Toronto","place":["Toronto, Canada"]},{"id":[{"id":"https:\/\/ror.org\/052gg0110","id-type":"ROR","asserted-by":"publisher"}],"name":"Mahidol Oxford Research Unit (MORU), Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford","place":["Oxford, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Moscatelli","sequence":"additional","affiliation":[{"name":"Servicio de Parasitolog\u00eda and Instituto Multidisciplinario de Investigaciones en Patolog\u00edas Pedi\u00e1tricas (IMIPP), CONICET-GCBA, Hospital de Ni\u00f1os Ricardo Gutierrez","place":["Buenos Aires, Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Moroni","sequence":"additional","affiliation":[{"name":"Servicio de Parasitolog\u00eda and Instituto Multidisciplinario de Investigaciones en Patolog\u00edas Pedi\u00e1tricas (IMIPP), CONICET-GCBA, Hospital de Ni\u00f1os Ricardo Gutierrez","place":["Buenos Aires, Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Servicio de Parasitolog\u00eda and Instituto Multidisciplinario de Investigaciones en Patolog\u00edas Pedi\u00e1tricas (IMIPP), CONICET-GCBA, Hospital de Ni\u00f1os Ricardo Gutierrez","place":["Buenos Aires, Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. C.","family":"Ramirez","sequence":"additional","affiliation":[{"name":"Servicio de Parasitolog\u00eda and Instituto Multidisciplinario de Investigaciones en Patolog\u00edas Pedi\u00e1tricas (IMIPP), CONICET-GCBA, Hospital de Ni\u00f1os Ricardo Gutierrez","place":["Buenos Aires, Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Garcia-Bournissen","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05cgtjz78","id-type":"ROR","asserted-by":"publisher"}],"name":"Division of Paediatric Clinical Pharmacology, Department of Paediatrics, Schulich School of Medicine and Dentistry, Western University","place":["London, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Ballering","sequence":"additional","affiliation":[{"name":"Servicio de Parasitolog\u00eda and Instituto Multidisciplinario de Investigaciones en Patolog\u00edas Pedi\u00e1tricas (IMIPP), CONICET-GCBA, Hospital de Ni\u00f1os Ricardo Gutierrez","place":["Buenos Aires, Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Freilij","sequence":"additional","affiliation":[{"name":"Servicio de Parasitolog\u00eda and Instituto Multidisciplinario de Investigaciones en Patolog\u00edas Pedi\u00e1tricas (IMIPP), CONICET-GCBA, Hospital de Ni\u00f1os Ricardo Gutierrez","place":["Buenos Aires, Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5865-7991","authenticated-orcid":true,"given":"J.","family":"Altcheh","sequence":"additional","affiliation":[{"name":"Servicio de Parasitolog\u00eda and Instituto Multidisciplinario de Investigaciones en Patolog\u00edas Pedi\u00e1tricas (IMIPP), CONICET-GCBA, Hospital de Ni\u00f1os Ricardo Gutierrez","place":["Buenos Aires, Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40475-020-00225-y"},{"key":"e_1_3_2_3_2","unstructured":"Winny A. 2022. 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