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This paper describes the design and synthesis of quinuclidine derivatives as potential inhibitors of a key enzyme in sterol biosynthesis, squalene synthase (SQS). A number of compounds that were inhibitors of the recombinant<jats:italic>Leishmania major<\/jats:italic>SQS at submicromolar concentrations were discovered. Some of these compounds were also selective for the parasite enzyme rather than the homologous human enzyme. The compounds inhibited the growth of and sterol biosynthesis in<jats:italic>Leishmania<\/jats:italic>parasites. In addition, we identified other quinuclidine derivatives that inhibit the growth of<jats:italic>Trypanosoma brucei<\/jats:italic>(the causative organism of human African trypanosomiasis) and<jats:italic>Plasmodium falciparum<\/jats:italic>(a causative agent of malaria), but through an unknown mode(s) of action.<\/jats:p>","DOI":"10.1128\/aac.00205-07","type":"journal-article","created":{"date-parts":[[2007,8,21]],"date-time":"2007-08-21T00:59:14Z","timestamp":1187657954000},"page":"4049-4061","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":40,"title":["Quinuclidine Derivatives as Potential Antiparasitics"],"prefix":"10.1128","volume":"51","author":[{"given":"Simon B.","family":"Cammerer","sequence":"first","affiliation":[{"name":"Welsh School of Pharmacy, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff CF10 3XF, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Jimenez","sequence":"additional","affiliation":[{"name":"Instituto de Parasitologi\u0301a y Biomedicina Lo\u0301pez-Neyra, Consejo Superior de Investigaciones Cienti\u0301ficas, Avda. del Conocimiento s\/n, Parque Tecnolo\u0301gico de Ciencias de la Salud, 18100-Armilla, Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Jones","sequence":"additional","affiliation":[{"name":"Welsh School of Pharmacy, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff CF10 3XF, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludovic","family":"Gros","sequence":"additional","affiliation":[{"name":"School of Life Sciences, University of Dundee, MSI\/WTB\/CIR Complex, Dow Street, Dundee DD1 5EH, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia Orenes","family":"Lorente","sequence":"additional","affiliation":[{"name":"Welsh School of Pharmacy, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff CF10 3XF, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Laboratorio de Qui\u0301mica Biolo\u0301gica, Centro de Biofisica y Bioqui\u0301mica, Instituto Venezolano de Investigaciones Cientificas, Altos de Pipe, Km. 11, Carretera Panamericana, Caracas 1020, Venezuela"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliany C. 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