{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T13:01:53Z","timestamp":1774270913788,"version":"3.50.1"},"reference-count":11,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2007,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            To evaluate empirical therapy with trimethoprim-sulfamethoxazole or doxycycline for outpatient skin and soft tissue infections in an area of high prevalence of methicillin-resistant\n            <jats:italic>Staphylococcus aureus<\/jats:italic>\n            , a randomized, prospective, open-label investigation was performed. The overall clinical failure rate was 9%, with all failures occurring in the trimethoprim-sulfamethoxazole group. However, there was no significant difference between the clinical failure rate of empirical trimethoprim-sulfamethoxazole therapy and that of doxycycline therapy.\n          <\/jats:p>","DOI":"10.1128\/aac.00206-07","type":"journal-article","created":{"date-parts":[[2007,5,15]],"date-time":"2007-05-15T00:58:40Z","timestamp":1179190720000},"page":"2628-2630","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":91,"title":["Prospective Randomized Trial of Empiric Therapy with Trimethoprim-Sulfamethoxazole or Doxycycline for Outpatient Skin and Soft Tissue Infections in an Area of High Prevalence of Methicillin-Resistant\n            <i>Staphylococcus aureus<\/i>"],"prefix":"10.1128","volume":"51","author":[{"given":"Mary Jo","family":"Cenizal","sequence":"first","affiliation":[{"name":"University of Texas Southwestern Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Skiest","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel","family":"Luber","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger","family":"Bedimo","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern Medical Center"},{"name":"VA North Texas Health Care System, Dallas, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pat","family":"Davis","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Fox","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen","family":"Delaney","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. 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Prospective comparison of methicillin-susceptible and methicillin-resistant community-associated Staphylococcus aureus infections in hospitalized patients. J. Infect.54:427-434.","journal-title":"J. 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