{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T19:24:30Z","timestamp":1762543470820,"version":"3.41.2"},"reference-count":17,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T00:00:00Z","timestamp":1626393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1128\/ASMCopyrightv2"},{"start":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T00:00:00Z","timestamp":1626393600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31872523"],"award-info":[{"award-number":["31872523"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"MOE | Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2019B04014"],"award-info":[{"award-number":["2019B04014"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2021,7,16]]},"abstract":"<jats:p>\n            Here, we characterized a carbapenem-resistant\n            <jats:named-content content-type=\"genus-species\">Vibrio diabolicus<\/jats:named-content>\n            strain of shrimp origin with various experiments and bioinformatics analysis. A novel metallo-\u03b2-lactamase (MBL) gene,\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>VMB-2<\/jats:sub>\n            , that confers resistance to \u03b2-lactams, including meropenem and cephalosporins, was identified on a plasmid-borne composite transposon, IS\n            <jats:italic>Shfr9<\/jats:italic>\n            -IS\n            <jats:italic>CR1<\/jats:italic>\n            -\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>VMB-2<\/jats:sub>\n            -\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>CARB-12<\/jats:sub>\n            -\n            <jats:italic>aadA1-<\/jats:italic>\n            IS\n            <jats:italic>Shfr9<\/jats:italic>\n            , which is capable of generating a\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>VMB-2<\/jats:sub>\n            -bearing circular intermediate. IS\n            <jats:italic>Shfr9<\/jats:italic>\n            was found to be disseminated in multidrug-resistant (MDR) pathogens, arousing the concern of further transmission of a\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>VMB-2<\/jats:sub>\n            -bearing circular intermediate to clinical\n            <jats:named-content content-type=\"genus-species\">Enterobacterales<\/jats:named-content>\n            strains via such insertion sequences, which warrants further investigations.\n          <\/jats:p>","DOI":"10.1128\/aac.00206-21","type":"journal-article","created":{"date-parts":[[2021,6,13]],"date-time":"2021-06-13T22:38:48Z","timestamp":1623623928000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":8,"title":["Identification of a Novel Plasmid-Mediated Carbapenemase-Encoding Gene,\n            <i>bla<\/i>\n            <sub>VMB-2<\/sub>\n            , in Vibrio diabolicus"],"prefix":"10.1128","volume":"65","author":[{"given":"Ming","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Marine Biology, College of Oceanography, Hohai University, Nanjing, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenhui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu Province, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Peng","sequence":"additional","affiliation":[{"name":"Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu Province, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiqiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu Province, People\u2019s Republic of China"},{"name":"Institute of Comparative Medicine, Yangzhou University, Yangzhou, Jiangsu Province, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8333-9891","authenticated-orcid":true,"given":"Ruichao","family":"Li","sequence":"additional","affiliation":[{"name":"Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu Province, People\u2019s Republic of China"},{"name":"Institute of Comparative Medicine, Yangzhou University, Yangzhou, Jiangsu Province, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2012.03.003"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2003407117"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00047-19"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkaa392"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/adbi.201900221"},{"key":"e_1_3_3_7_2","volume-title":"Methods for antimicrobial dilution and disk susceptibility testing of infrequently isolated or fastidious bacteria","author":"Clinical and Laboratory Standards Institute.","year":"2016","unstructured":"Clinical and Laboratory Standards Institute. 2016. Methods for antimicrobial dilution and disk susceptibility testing of infrequently isolated or fastidious bacteria, 3rd ed. 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